Novel series of tunable µOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications

Publication date: 15 August 2023Source: Bioorganic & Medicinal Chemistry Letters, Volume 92Author(s): Alok Nerurkar, Thomas Nguyen, Sheldon Wang, Ulhas Bhatt, Kevin Li, Yihong Li, Pingyu Ding, Frederick J. Seidl, Martin Holan, John Lee, Tien Widjaja, Z…

Synthesis of 1-(4-(Dimethylamino)phenyl)-3,4-diphenyl-1<em>H</em>-pyrrole-2,5-dione Analogues and their Anti-inflammatory Activities in Lipopolysaccharide-Induced BV2 Cells

Publication date: Available online 8 July 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Hyo Jae Jung, Duk-Yeon Cho, Jun-Hyuk Han, Ki Dong Park, Dong-Kug Choi, Eunha Kim, Sung-Hwa Yoon, Ju-Young Park