Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506

Publication date: Available online 25 August 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Andrew G. Cole, Steven G. Kultgen, Nagraj Mani, Jorge G. Quintero, Kristi Yi Fan, Andrzej Ardzinski, Kim Stever, Bruce D. Dorsey, Janet R. Phelp…

Synthesis and biological evaluation of simplified ajudazol derivatives reveal potent 5-lipoxygenase inhibition and considerable apoptotic activity in neuroblastoma cells

Publication date: 1 October 2023Source: Bioorganic & Medicinal Chemistry Letters, Volume 94Author(s): Philipp Wollnitzke, Raphael Wagner, Sumaiya Yasmeen Afsar, Markus Werner, Robin Geschold, Christa E. Müller, Oliver Werz, Gerhild van Echten-Deckert, …