Design, synthesis and evaluation of novel thieno[2,3<em>d</em>]pyrimidine derivatives as potent and specific RIPK2 inhibitors

Publication date: 15 December 2023Source: Bioorganic & Medicinal Chemistry Letters, Volume 97Author(s): Mbilo Misehe, Michal Šála, Marika Matoušová, Kamil Hercík, Hugo Kocek, Dominika Chalupská, Ema Chaloupecká, Miroslav Hájek, Evzen Boura, Helena Mert…

Azetidine ring, salicylic acid, and salicylic acid bioisosteres as determinants of the binding characteristics of novel potent compounds to Stat3

Publication date: 15 December 2023Source: Bioorganic & Medicinal Chemistry Letters, Volume 97Author(s): Yue Chen, Ning Zhai, Yinsong Zhu, Peibin Yue, Nagendra Verma, Christine Brotherton-Pleiss, Wenzhen Fu, Kayo Nakamura, Weiliang Chen, Joel Kawakami, …

Optimizing and characterizing 4-methyl substituted pyrazol-3-carboxamides leading to the peripheral cannabinoid 1 receptor inverse agonist TM38837

Publication date: Available online 1 December 2023Source: Bioorganic & Medicinal Chemistry LettersAuthor(s): Thomas Högberg, Jean-Marie Receveur, Anthony Murray, Jean-Michel Linget, Pia K. Nørregaard, Paul B. Little, Martin Cooper