Cell-active, irreversible covalent inhibitors that selectively target the catalytic lysine of EGFR by using fluorosulfate-based SuFEx chemistry

Publication date: 5 November 2023Source: European Journal of Medicinal Chemistry, Volume 259Author(s): Guanghui Tang, Wei Wang, Xuan Wang, Ke Ding, SoFong Cam Ngan, Jiao-Yu Chen, Siu Kwan Sze, Liqian Gao, Peiyan Yuan, Xiaoyun Lu, Shao Q. Yao

Identification of novel tetrahydroquinoxaline derived phenyl ureas as modulators of the hepatitis B virus nucleocapsid assembly

Publication date: 5 November 2023Source: European Journal of Medicinal Chemistry, Volume 259Author(s): Nicky Hwang, Shuo Wu, Haiqun Ban, Huixin Luo, Julia Ma, Junjun Cheng, Qiong Zhao, Jessilyn A. Laney, Na Du, Junyang Guo, Manasa Suresh, Liangxian She…

Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments

Publication date: 5 November 2023Source: European Journal of Medicinal Chemistry, Volume 259Author(s): Ahmed A. Al-Karmalawy, Mahmoud Rashed, Marwa Sharaky, Hamada S. Abulkhair, Mohamed M. Hammouda, Haytham O. Tawfik, Moataz A. Shaldam

Discovery and structure-activity relationship studies of novel α-ketoamide derivatives targeting the SARS-CoV-2 main protease

Publication date: 5 November 2023Source: European Journal of Medicinal Chemistry, Volume 259Author(s): Chong Huang, Rui Zeng, Jingxin Qiao, Baoxue Quan, Ronghua Luo, Qiao Huang, Nihong Guo, Yueyue Li, Xinyan Long, Ronggang Ma, Anjie Xia, Zhen Fang, Yif…