Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson’s disease

Publication date: 5 July 2023Source: European Journal of Medicinal Chemistry, Volume 255Author(s): Zhen-Bao Shen, Hua-Wen Meng, Xian-She Meng, Ze-Kun Lv, Meng-Yuan Fang, Lang-Lang Zhang, Zhi-Lin Lv, Mu-Sen Li, An-Kang Liu, Ji-Hong Han, Qing-Shan Li, Ya…

Application of an “inhalation by design” approach to the identification and in-vitro evaluation of novel purine based PI3Kδ inhibitors

Publication date: 5 June 2023Source: European Journal of Medicinal Chemistry, Volume 254Author(s): Roberta Mazzucato, Marinella Roberti, Anna Maria Capelli, Fabio Rancati, Matteo Biagetti, Claudio Fiorelli, Paolo Bruno, Paolo Ronchi, Serena Bertolini, …

New miconazole-based azoles derived from eugenol show activity against <em>Candida</em> spp. and <em>Cryptococcus gattii</em> by inhibiting the fungal ergosterol biosynthesis

Publication date: Available online 1 May 2023Source: European Journal of Medicinal ChemistryAuthor(s): Vinícius Augusto Campos Péret, Rúbia Castro Fernandes Melo Reis, Saulo Fehelberg Pinto Braga, Monique Dias Benedetti, Ivo Santana Caldas, Diogo Teixe…