C(21)-fluorinated thevinol scaffold for opioid ligands. 21,21,21-Trifluoro-6-<em>O</em>-nororvinols: Design, synthesis and analgesic activity

Publication date: Available online 22 March 2023Source: European Journal of Medicinal ChemistryAuthor(s): Irina V. Sandulenko, Irina V. Belozertseva, Edwin E. Zvartau, Maria V. Zelentsova, Asmik A. Ambartsumyan, Alexander F. Smol’yakov, Sergey K. Moiseev

Discovery of <em>N</em>-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties

Publication date: 5 April 2023Source: European Journal of Medicinal Chemistry, Volume 252Author(s): Ruifang Jia, Jiwei Zhang, Fangyuan Shi, Anna Bonomini, Camilla Lucca, Chiara Bertagnin, Jian Zhang, Chuanfeng Liu, Huinan Jia, Yuanmin Jiang, Xiuli Ma, …

Structure-activity relationships of actively FhuE transported rifabutin derivatives with potent activity against <em>Acinetobacter baumannii</em>

Publication date: 5 April 2023Source: European Journal of Medicinal Chemistry, Volume 252Author(s): M. Maingot, M. Bourotte, A.C. Vetter, B. Schellhorn, K. Antraygues, H. Scherer, M. Gitzinger, C. Kemmer, G.E. Dale, O. Defert, S. Lociuro, M. Brönstrup,…

Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities

Publication date: 5 April 2023Source: European Journal of Medicinal Chemistry, Volume 252Author(s): Gang Li, Jia-Qiang Wu, Xiaojia Cai, Wen Guan, Zhijun Zeng, Yanghui Ou, Xiaoyun Wu, Jiayu Li, Xiangxiang Fang, Jinling Liu, Yali Zhang, Huamin Wang, Canq…