Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents – Design, synthesis, structural studies and pharmacological profiling

Publication date: Available online 17 March 2023Source: European Journal of Medicinal ChemistryAuthor(s): Piotr Stępnicki, Katarzyna M. Targowska-Duda, Antón L. Martínez, Agata Zięba, Olga Wronikowska-Denysiuk, Martyna Z. Wróbel, Agata Bartyzel, Alicja…

Synthesis and biological evaluation of theranostic Trastuzumab–SN38 conjugate for Near-IR fluorescence imaging and targeted therapy of HER2+ breast cancer

Publication date: Available online 22 March 2023Source: European Journal of Medicinal ChemistryAuthor(s): Dmytro Kobzev, Chandrashekhar Prasad, Dipak Walunj, Hodaya Gotman, Olga Semenova, Andrii Bazylevich, Leonid Patsenker, Gary Gellerman

Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids – Design, synthesis, and biological evaluation

Publication date: Available online 22 March 2023Source: European Journal of Medicinal ChemistryAuthor(s): Filip Pidany, Jana Kroustkova, Abdullah Al Mamun, Daniela Suchankova, Xavier Brazzolotto, Florian Nachon, Fabien Chantegreil, Rafael Dolezal, Lenk…