A visible-light-mediated C-3 formylation of indole catalyzed by eosin Y has been developed using tetramethylethylenediamine as a carbon source and air as an oxidant. This protocol shows high tolerance to a large quantity of functional groups under mild conditions and provides 3-formylated indoles with good yields. This method is a highly attractive alternative to the approach of traditional formylation.
A method for assembling chalcones, glycine ethyl ester hydrochloride, and elemental sulfur toward a synthesis of 4,5-disubstituted thiazoles is reported. The transformation presumably proceeds via a sequence of β-C–H amination, annulation, and dealkoxycarbonylation. This tactic represents a rare example of a method for obtaining such disubstituted thiazoles directly from chalcone C–H bonds.
Journal of Physical Organic Chemistry, Volume 35, Issue 6, June 2022.
Chemistry–Methods, Volume 2, Issue 10, October 2022.
Journal of Physical Organic Chemistry, Volume 36, Issue 12, December 2023.
ChemMedChem, Volume 17, Issue 9, May 4, 2022.
ChemMedChem, Volume 17, Issue 9, May 4, 2022.
ChemMedChem, Volume 17, Issue 9, May 4, 2022.
European Journal of Organic Chemistry, EarlyView.