Nature Biotechnology, Published online: 07 October 2024; doi:10.1038/s41587-024-02386-xOptical pooled CRISPR screening is improved by combinatorial oligo hybridization for barcode detection.
Nature Biotechnology, Published online: 07 October 2024; doi:10.1038/s41587-024-02403-zPhenotypic screens in organoids and primary cells are scaled up using perturbation pooling.
Nature Biotechnology, Published online: 04 October 2024; doi:10.1038/s41587-024-02418-6Bacteria expressing an anti-tumor cytokine act as a potent cancer immunotherapy.
Nature Biotechnology, Published online: 04 October 2024; doi:10.1038/s41587-024-02429-3Escherichia coli engineered to display cytokines destroy hard-to-treat tumors by boosting the activity of local native and adoptive immune effector …
Nature Biotechnology, Published online: 02 October 2024; doi:10.1038/s41587-024-02435-5The FDA’s approval of the first genetically modified T cell therapy for treating a rare sarcoma is paving the way for next-generation therapies that…
Nature Biotechnology, Published online: 30 September 2024; doi:10.1038/s41587-024-02394-xLong, chemically modified pegRNAs are rapidly synthesized using an optimized splint ligation approach.
Nature Biotechnology, Published online: 25 September 2024; doi:10.1038/s41587-024-02405-xPrime editing efficiency is enhanced using a mutated reverse transcriptase and addition of deoxynucleosides.
Nature Biotechnology, Published online: 25 September 2024; doi:10.1038/s41587-024-02395-wProteinGenerator simultaneously generates protein sequences and structures using sequence space diffusion.
Nature Biotechnology, Published online: 23 September 2024; doi:10.1038/s41587-024-02393-ymRNA cap designs boost translation >10-fold, with potential benefits for RNA therapies.
Nature Biotechnology, Published online: 23 September 2024; doi:10.1038/s41587-024-02381-2SPLASH2 speeds up analysis of sequence variation in massive datasets.