Nature Biotechnology
Niemann–Pick double win
Nature Biotechnology, Published online: 14 October 2024; doi:10.1038/s41587-024-02450-6Niemann–Pick double win
Nature Biotechnology
A strategy to load, rethread and read protein sequences through a nanopore
Nature Biotechnology, Published online: 14 October 2024; doi:10.1038/s41587-024-02443-5A strategy to load, rethread and read protein sequences through a nanopore
Nature Biotechnology
Biotech news from around the world
Nature Biotechnology, Published online: 14 October 2024; doi:10.1038/s41587-024-02436-4Biotech news from around the world
Nature Biotechnology
Pan-KRAS destruction with a single PROTAC
Nature Biotechnology, Published online: 14 October 2024; doi:10.1038/s41587-024-02445-3Pan-KRAS destruction with a single PROTAC
Nature Biotechnology
A community effort to optimize sequence-based deep learning models of gene regulation
Nature Biotechnology, Published online: 11 October 2024; doi:10.1038/s41587-024-02414-wA benchmarking competition improves tools that predict how regulatory regions control gene expression.
Nature Biotechnology
A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy
Nature Biotechnology, Published online: 11 October 2024; doi:10.1038/s41587-024-02420-yThe neoantigen discovery pipeline NeoDisc incorporates mass spectrometry immunopeptidomics data.
Nature Biotechnology
Model-directed generation of artificial CRISPR–Cas13a guide RNA sequences improves nucleic acid detection
Nature Biotechnology, Published online: 11 October 2024; doi:10.1038/s41587-024-02422-wModel-directed generative design is applied to CRISPR–Cas13a guide RNAs, outperforming natural sequences.
Nature Biotechnology
An antigen discovery pipeline integrates multi-omics data and informs immunotherapy
Nature Biotechnology, Published online: 11 October 2024; doi:10.1038/s41587-024-02427-5We developed NeoDisc, a computational antigen discovery pipeline that integrates multi-omics data, including genomics, transcriptomics and mass spec…
Nature Biotechnology
A circularly permuted CasRx platform for efficient, site-specific RNA editing
Nature Biotechnology, Published online: 09 October 2024; doi:10.1038/s41587-024-02430-wSite-specific and efficient RNA editing is achieved with a CasRx editor.
Nature Biotechnology
One-step nanoscale expansion microscopy reveals individual protein shapes
Nature Biotechnology, Published online: 09 October 2024; doi:10.1038/s41587-024-02431-9Combining expansion microscopy with super-resolution radial fluctuations captures the morphology of single proteins.