Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>The polymerase chain reaction (PCR) amplification process of deoxyribonucleic acid (DNA) libraries can introduce bias in the sequence ratios. Consequently, several recent genomic and transcriptomic methods employing next-generation sequencing (NGS) …
Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>Colorectal cancer (CRC) remains a leading cause of global cancer mortality, underscoring the need for novel therapeutic strategies. This study used a systems pharmacology approach integrated with molecular docking and molecular dynamics (MD) simulations …
Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>Over 6 million people are estimated to have been living with Alzheimer disease (AD) in 2020, with another 12 million living with Mild Cognitive Impairment (MCI). Research has been conducted to evaluate genetic links to AD, but more research is needed to …
Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>The kidneys are vital organs responsible for filtering and eliminating toxins from the body. Chronic kidney disease (CKD) is becoming increasingly prevalent, affecting not only older adults but also younger populations. To minimize kidney damage for those …
Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>The re-emergence of monkeypox virus (MPXV) as a global public health concern highlights the urgent need for novel therapeutic strategies targeting viral proteins essential for infection. This study investigates the inhibitory potential of Trans-…
Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>WNT proteins constitute a highly conserved family of signaling molecules that play an important role in regulating embryonic development and maintaining adult tissue homeostasis. Their diverse biological functions are mediated through multiple signaling …
Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>Nectin-1/herpes simplex virus glycoprotein D (HSV gD) interaction is crucial to drive herpes simplex virus (HSV) entry. Polyanions are known to show great potential as antivirals. Thus, we explored a peptide-based biotherapeutic approach and, for the …
Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>Coronary artery disease (CAD) and peripheral artery disease have serious effects on quality of life. Recent studies have shown that peripheral arterial disorders increase a person’s risk of developing CAD. The clinical symptoms of these conditions include …
Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>Avian coccidiosis, caused by Eimeria protozoa, presents a significant threat to poultry, withEimeria tenellabeing particularly harmful due to its impact on the chicken cecum. Growing resistance to current treatments necessitates alternative therapeutic …
Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>Automated leaf segmentation pipelines must balance accuracy, scalability, and usability to be readily adopted in plant research. We present an end-to-end deep learning pipeline designed for practical use in plant phenotyping, which we developed and …