Bioinformatics and Biology Insights

Designing a Multi-Epitope Vaccine Against HPV 16, 18, 33, and 45 Targeting L1 and E7 Proteins: An Immunoinformatics Approach for Cervical Cancer Prevention and Therapy

Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>Cervical cancer, induced by human papillomavirus (HPV), ranks as the fourth most prevalent malignancy among women globally. Unfortunately, existing prophylactic vaccines lack therapeutic efficacy. This study aimed to design a multi-epitope vaccine …

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A Deep Learning Model to Predict the ncRNA-Protein Interactions Based on Sequences Information Only

Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>Noncoding RNAs (ncRNAs) play significant roles in multiple fundamental biological processes, in particular, ncRNAs interactions provide valuable insights into protein synthesis, controlling gene expression, RNA processing, regulation of localization, etc. …

By Maha FM Sewailem, Muhammad Arif, Tanvir Alam, ago

Identification of Potent HDAC6 Inhibitors for Breast Cancer Through Multi-Stage In Silico Modeling

Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>Histone deacetylases (HDACs) are essential epigenetic regulators, with HDAC6 overexpression linked to estrogen receptor (ER) activity and breast cancer progression. While several HDAC6 inhibitors have been investigated, their clinical success remains …

By Vaishali Pankaj, Inderjeet Bhogal, Sudeep Roy, ago

Understanding the Impact of Individual Nucleotide on Oxford Nanopore Current Signals With Interpretable Prediction Models

Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>Oxford nanopore sequencing enabled real-time, long-read analysis of DNA by detecting ionic current signals associated with K-mer sequences. Although many studies analyzed sequence and modification detection, our understanding of how multiple nucleotides …

By Yenan Wang, Zhixing Wu, Jia Meng, ago

Metagenomic Insights Into Biopile Remediation of Petroleum-Contaminated Soil Using Chicken Droppings in Rivers State, Nigeria

Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>Petroleum hydrocarbon pollution is an escalating global issue, particularly in developing countries, where it has attracted significant attention from researchers focusing on bioremediation, monitoring and sustainability. This study utilised metagenomics …

By Emmanuel O Fenibo, Rosina Nkuna, Tonderayi Matambo, ago

Repurposing of Anti-Infectives for the Management of Onchocerciasis Using Machine Learning and Protein Docking Studies

Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>There is a need to improve the discovery of new drugs for neglected tropical diseases (NTDs), as the lack of financial incentives has slowed their development. Currently, ivermectin and moxidectin are used in the management of onchocerciasis. We present a …

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Language Modelling Techniques for Analysing the Impact of Human Genetic Variation

Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>Interpreting the effects of variants within the human genome and proteome is essential for analysing disease risk, predicting medication response, and developing personalised health interventions. Due to the intrinsic similarities between the structure of …

By Megha Hegde, Jean-Christophe Nebel, Farzana Rahman, ago

R2eGIN: Residual Reconstruction Enhanced Graph Isomorphism Network for Accurate Prediction of Poly (ADP–Ribose) Polymerase Inhibitors

Bioinformatics and Biology Insights, Volume 19, January-December 2025. <br/>An advanced graph neural network (GNN) is of great promise to facilitate predicting Poly ADPribose polymerase inhibitors (PARPi). Recent studies design models by leveraging graph representations and molecular descriptor representations, unfortunately, …

By Candra Zonyfar, Soualihou Ngnamsie Njimbouom, Sophia Mosalla, Jeong-Dong Kim, ago