AbstractCancer cells acquire necessary functional capabilities for malignancy through the influence of the nervous system. We evaluate the extent of neural infiltration within the tumor microenvironment (TME) across multiple cancer types, highlighting …
AbstractSpatial transcriptomics (ST) technology provides gene expression profiles with spatial context, offering critical insights into cellular interactions and tissue architecture. A core task in ST is spatial domain identification, which involves de…
AbstractCancer neoantigens are peptides that originate from alterations in the genome, transcriptome, or proteome. These peptides can elicit cancer-specific T-cell recognition, making them potential candidates for cancer vaccines. The rapid advancement…
AbstractMotivationProtein–protein interactions play a fundamental role in biological systems. Accurate detection of protein–protein interaction sites (PPIs) remains a challenge. And, the methods of PPIs prediction based on biological experiments are ex…
AbstractMotivationThe 3D organization of the genome plays a crucial role in various biological processes. Hi-C technology is widely used to investigate chromosome structures by quantifying 3D proximity between genomic regions. While numerous computatio…
AbstractMicrobes have a profound impact on human health. Identifying disease-associated microbes would provide helpful guidance for drug development and disease treatment. Through an enormous experimental effort, limited disease-associated microbes hav…
AbstractComprehensive 2D gas chromatography coupled with mass spectrometry (GC × GC–MS) is a powerful analytical technique. However, the complexity and volume of data generated pose significant challenges for data processing and interpretation, limitin…
AbstractCopy number alterations (CNAs) are an important type of genomic variation which play a crucial role in the initiation and progression of cancer. With the explosion of single-cell RNA sequencing (scRNA-seq), several computational methods have be…