Bioorganic Chemistry

Modified peroxamide-based reactive oxygen species (ROS)-responsive doxorubicin prodrugs

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Mina Jafari, Vishnu Sriram, Gurdat Premnauth, Edward Merino, Joo-Youp Lee

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer’s disease

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Martha Velueta-Viveros, Macarena Martínez-Bailén, Adrián Puerta, Laura L. Romero-Hernández, Vladimír Křen, Penélope Merino-Montiel, Sara Montiel-Smith, Miguel X. Fernandes…

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

A novel long excitation/emission wavelength fluorophore as platform utilized to construct NIR probes for bioimaging and biosensing

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Jingcan Qin, Hao Tian, Fei Kong, Qian qian Zhao, Chuan Zhang, Hongmei Gu, Yuehua Li

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

One pot domino synthesis of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thiones (THTTs) as anti-inflammatory and antinociceptive candidates: A proof from in-vivo to in-vitro and in-silico mechanistic studies

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Sumaya Raheem, Rasool Khan, Xiandao Pan, Rahim Ullah, Sobia Ahsan Halim, Ajmal Khan, Ahmed Al-Harrasi

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Discovery of benzamide derivatives containing urea moiety as soluble epoxide hydrolase inhibitors

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Ye Tian, Shuo Li, Kuan Dong, Xiaolu Su, Siyu Fu, Xuening Lv, Meibo Duan, Ting Yang, Yu Han, Guangda Hu, Jialu Liu, Yanping Sun, Hao Yue, Yongjun Sun, Huimin Zhang, Zhidian…

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Hexa-substituted cyclotriphosphazene derivatives containing hetero-ring chalcones: Synthesis, in vitro cytotoxic activity and their DNA damage determination

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Asiye Beytur, Çiğdem Tekin, Eray Çalışkan, Suat Tekin, Kenan Koran, Ahmet Orhan Görgülü, Süleyman Sandal

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Discovery of novel 4-arylamino-quinazoline derivatives as EGFRL858R/T790M inhibitors with the potential to inhibit the non-small cell lung cancers

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Wenhui Gan, Caolin Wang, Qingshan Pan, Yuzhen Li, Yuping Guo, Dang Fan, Yuting Peng, Zixuan Rao, Shan Xu, Pengwu Zheng, Wufu Zhu

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

SAR study culminates in a series of HDAC6 selective inhibitors featuring Schisandrin C-analogous Cap as potential immunomodulatory agents for cancer therapy

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Qiangqiang Tao, Wei Wei, Xiaoqing Lv, Jian Guo, Yaotian Tao, Mingming Zhang, Ge He, Zhi Li, Shuangying Gui, Xiaodong Ma

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Mohamed M. Hammouda, Ayman Abo Elmaaty, Mohamed S. Nafie, Marwa Abdel-Motaal, Noha S. Mohamed, Mohamed A. Tantawy, Amany Belal, Radwan Alnajjar, Wagdy M. Eldehna, Ahmed A….

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Cadinane-type sesquiterpenoid dimeric diastereomers hibisceusones A-C from infected stems of Hibiscus tiliaceus with cytotoxic activity against triple-negative breast cancer cells

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): De-Li Chen, Guo-Xu Ma, Er-Lan Yang, Yun Yang, Can-Hong Wang, Zhao-Cui Sun, Han-Qiao Liang, Xu-Dong Xu, Jian-He Wei

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Bioorganic Chemistry

Modified peroxamide-based reactive oxygen species (ROS)-responsive doxorubicin prodrugs

Bioorganic Chemistry

Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer’s disease

Bioorganic Chemistry

A novel long excitation/emission wavelength fluorophore as platform utilized to construct NIR probes for bioimaging and biosensing

Bioorganic Chemistry

One pot domino synthesis of new 3,5-disubstituted-tetrahydro-2<em>H</em>-1,3,5-thiadiazine-2-thiones (THTTs) as anti-inflammatory and antinociceptive candidates: A proof from <em>in-vivo</em> to <em>in-vitro</em> and <em>in-silico</em> mechanistic studies

Bioorganic Chemistry

Discovery of benzamide derivatives containing urea moiety as soluble epoxide hydrolase inhibitors

Bioorganic Chemistry

Hexa-substituted cyclotriphosphazene derivatives containing hetero-ring chalcones: Synthesis, <em>in vitro</em> cytotoxic activity and their DNA damage determination

Bioorganic Chemistry

Discovery of novel 4-arylamino-quinazoline derivatives as EGFR<sup>L858R/T790M</sup> inhibitors with the potential to inhibit the non-small cell lung cancers

Bioorganic Chemistry

SAR study culminates in a series of HDAC6 selective inhibitors featuring Schisandrin C-analogous Cap as potential immunomodulatory agents for cancer therapy

Bioorganic Chemistry

Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: <em>In Vitro</em>, <em>in Vivo</em>, molecular docking, molecular dynamics, and SAR studies

Bioorganic Chemistry

Cadinane-type sesquiterpenoid dimeric diastereomers hibisceusones A-C from infected stems of <em>Hibiscus tiliaceus</em> with cytotoxic activity against triple-negative breast cancer cells