Department of Biotechnology and Bioinformatics

Bioorganic Chemistry

Bioorganic Chemistry

Development of benztropine-based DAT blockers for Parkinson’s disease interventions: A biologic and synthetic overview

Publication date: January 2026Source: Bioorganic Chemistry, Volume 168Author(s): Edson D. Hernández-Velázquez, Rubén Chávez-Rivera, Rafael Ortíz-Alvarado, César R. Solorio-Alvarado

By ScienceDirect Publication: Bioorganic Chemistry, 2 days ago
Bioorganic Chemistry

Tackling the challenge of ML-assisted antibacterial activity prediction: One step closer to controlled quaternary ammonium compounds design via neural networks model

Publication date: December 2025Source: Bioorganic Chemistry, Volume 167Author(s): Egor A. Ilin, Nikita A. Frolov, Mary A. Seferyan, Anvar B. Valeev, Andrey D. Vinokurov, Elena V. Detusheva, Elizabeth Son, Michael G. Medvedev, Anatoly N. Vereshchagin

By ScienceDirect Publication: Bioorganic Chemistry, 3 days ago
Bioorganic Chemistry

Evaluation of anti-tumor activity of borated camptothecin derivatives targeting topoisomerase 1 against hepatocellular carcinoma and intrahepatic cholangiocarcinoma

Publication date: December 2025Source: Bioorganic Chemistry, Volume 167Author(s): Mi Zhang, Yifei Xiang, Chun Li, Chuanrui Xu, Guisha Chen, Ruitao Long, Chanyuan Chen, Yingqian Liu, Feng Ye

By ScienceDirect Publication: Bioorganic Chemistry, 3 days ago
Bioorganic Chemistry

Design, synthesis, and biological evaluation of kenpaullone derivatives as potential dual inhibitors of cholinesterases and glycogen synthase kinase-3β

Publication date: December 2025Source: Bioorganic Chemistry, Volume 167Author(s): Rinky Raghuvanshi, Satish C. Wakudkar, Sudhakar Manda, Sandip B. Bharate

By ScienceDirect Publication: Bioorganic Chemistry, 3 days ago
Bioorganic Chemistry

Novel 2-oxoethylthio-sulfonamide derivatives targeting pyocyanin/staphyloxanthin producing-pathogens: Antibiofilm, DHPS inhibition and gamma radiation effects

Publication date: December 2025Source: Bioorganic Chemistry, Volume 167Author(s): Mostafa M. Ghorab, Dina S. Aboul-Magd, Aiten M. Soliman

By ScienceDirect Publication: Bioorganic Chemistry, 3 days ago
Bioorganic Chemistry

Discovery of a dual-functional β-carboline fluorescent probe for detection and treatment of H<sub>2</sub>O<sub>2</sub>-induced cardiomyocyte oxidative injury

Publication date: December 2025Source: Bioorganic Chemistry, Volume 167Author(s): Rong-Hong Zhang, Wen-Li Zhang, Jin-Feng Long, Hai-Dong He, Rui-Xi Li, Yong-Jun Li, Meng Zhou

By ScienceDirect Publication: Bioorganic Chemistry, 3 days ago
Bioorganic Chemistry

Selective membrane disrupting dispiro-oxindole Dehydrocostuslactone hybrids with potent anti-MRSA, antibiofilm, and synergistic activity

Publication date: December 2025Source: Bioorganic Chemistry, Volume 167Author(s): Anil Bhushan, Arti Rathore, Vivek Singh Baghel, Shifa Firdous, Urvashi Dhiman, Biplab Sarkar, Yogesh P. Bharitkar, Prasoon Gupta, Avisek Mahapa, Ravindra S. Phatake

By ScienceDirect Publication: Bioorganic Chemistry, 3 days ago
Bioorganic Chemistry

Bioactive flavonoids from <em>Ohwia caudata</em> stems influence small intestinal motility <em>ex vivo</em>

Publication date: December 2025Source: Bioorganic Chemistry, Volume 167Author(s): Jingya Ruan, Dingshan Yang, Qianqian Geng, Jia Hao, Yingying Wang, Yu Han, Fei Li, Huina Cao, Yi Zhang, Tao Wang

By ScienceDirect Publication: Bioorganic Chemistry, 3 days ago
Bioorganic Chemistry

Identification of 2,4-disubstitued pyridine derivatives as potent FMS-like tyrosine receptor kinase 3 (FLT3) inhibitors

Publication date: December 2025Source: Bioorganic Chemistry, Volume 167Author(s): Zhongyuan Wang, Xinfu Liu, Youli Hou, Dongdong Cao, Shiyu Hu, Lihong He, Yiwei Zhang, Dongsheng Zhao, Rui Chen, Wenzhang Chen, Aihong Li, Weiwei Ouyang, Weike Liao

By ScienceDirect Publication: Bioorganic Chemistry, 3 days ago
Bioorganic Chemistry

Glycolysis-mediated energy metabolism mechanisms: Synergistic antifungal activity of (±)-methylagrimonolide against drug-resistant <em>Candida albicans</em>

Publication date: December 2025Source: Bioorganic Chemistry, Volume 167Author(s): Fei Chen, Xiao Zhang, Rui Guo, Xianhu Zhu, Zewei Mao, Ruirui Wang

By ScienceDirect Publication: Bioorganic Chemistry, 3 days ago

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