Nature Chemical Biology, Published online: 13 August 2024; doi:10.1038/s41589-024-01703-4Dynamic metabolic signatures underpin B cell function throughout development, maturation and differentiation. Germinal center B cells rely on MTHF…
Nature Chemical Biology, Published online: 13 August 2024; doi:10.1038/s41589-024-01698-yUnderstanding the physiological effects of antibiotics on bacterial cells is important for informing antibiotic use. Bacterial communities treated…
Nature Chemical Biology, Published online: 05 August 2024; doi:10.1038/s41589-024-01704-3High-content screening of a natural diterpenoid library identified a highly potent anti-liver fibrosis lead, 12-deoxyphorbol 13-palmitate (DP), wh…
Nature Chemical Biology, Published online: 05 August 2024; doi:10.1038/s41589-024-01684-4Profiling endogenous Ras (rat sarcoma virus) activity during Ras-G12C inhibition at the single-cell level revealed signaling and metabolic changes…
Nature Chemical Biology, Published online: 01 August 2024; doi:10.1038/s41589-024-01692-4Takato et al. developed a light-driven, singlet oxygen-mediated proximity labeling method termed PhoxID to identify the local proteomes of endogen…
Nature Chemical Biology, Published online: 01 August 2024; doi:10.1038/s41589-024-01694-2How dynein moves in living cells remains unclear. Here the authors develop a photostable probe that enables long-term single-cargo tracking in liv…
Nature Chemical Biology, Published online: 31 July 2024; doi:10.1038/s41589-024-01682-6Fluorine-19 NMR analysis combined with molecular dynamics and Monte Carlo simulations captures the activation ensemble and associated dynamics of ad…
Nature Chemical Biology, Published online: 30 July 2024; doi:10.1038/s41589-024-01700-7Computational methods for calculating a protein structure from a given amino acid sequence have revolutionized both our understanding of structural …
Nature Chemical Biology, Published online: 30 July 2024; doi:10.1038/s41589-024-01686-2The biosynthetic intermediate of the common core of enediyne natural products has been enigmatic for decades. Now, researchers report the identifica…
Nature Chemical Biology, Published online: 29 July 2024; doi:10.1038/s41589-024-01693-3Shu et al. showed that clustered regularly interspaced short palindromic repeat (CRISPR)-repressed toxins defend CRISPR–Cas against various anti-CRI…