Nature Chemical Biology, Published online: 24 March 2022; doi:10.1038/s41589-022-00996-7Identification of genes associated with resistance to hundreds of cancer therapeutics enabled the discovery of the serine hydrolases MGLL and CES1 …
Nature Chemical Biology, Published online: 24 March 2022; doi:10.1038/s41589-022-00980-1Precision oncology requires an understanding of the genes and pathways that dictate therapeutic response. Through specialized analysis of drug sens…
Nature Chemical Biology, Published online: 24 March 2022; doi:10.1038/s41589-022-00986-9Chemoproteomics reveals a cysteine oxidation event that inhibits the maturation process of a lysosomal protease, enabling its secretion into the ex…
Nature Chemical Biology, Published online: 21 March 2022; doi:10.1038/s41589-022-00993-wBiochemical and structural characterization of a standalone ketosynthase, SalC, reveals that it serves as a critical intramolecular aldolase and β-…
Nature Chemical Biology, Published online: 21 March 2022; doi:10.1038/s41589-022-00985-wThe use of NMR spectroscopy and development of a cellular BRET KRAS engagement assay revealed that noncovalent ligands can access the switch-II poc…
Nature Chemical Biology, Published online: 21 March 2022; doi:10.1038/s41589-022-01000-yDespite well-established tumorigenic roles of KRAS mutants, targeting their smooth surfaces was a challenge, which was overcome through the develop…
Nature Chemical Biology, Published online: 17 March 2022; doi:10.1038/s41589-022-00998-5Natural self-cleaving RNAs employ a wide range of catalytic strategies, but it is not known whether artificial ribozymes are capable of the same ca…