Nature Chemical Biology, Published online: 11 August 2022; doi:10.1038/s41589-022-01093-5A combination of mass spectrometry, pooled genome screens and STRING analysis identifies key uptake mediating interactions between nanoparticle-ad…
Nature Chemical Biology, Published online: 11 August 2022; doi:10.1038/s41589-022-01090-8Bicyclostreptins are peptide natural products in which a macrocyclic β-ether and a heterocyclic sp3–sp3 linkage between a backbone amide nitrogen …
Nature Chemical Biology, Published online: 11 August 2022; doi:10.1038/s41589-022-01108-1Elucidating the interactions between serum protein-bound nanoparticles and cell-surface receptors typically operates on a per protein–receptor int…
Nature Chemical Biology, Published online: 01 August 2022; doi:10.1038/s41589-022-01077-5A hypercompact adenine base editor termed TaRGET-ABE was developed by fusing a catalytically inactive transposon-associated transposase B guided b…
Nature Chemical Biology, Published online: 01 August 2022; doi:10.1038/s41589-022-01101-8Transposon-associated transposase B (TnpB) is the putative ancestor of Cas nucleases. A TnpB-based adenine base editor has now been developed that…
Nature Chemical Biology, Published online: 27 July 2022; doi:10.1038/s41589-022-01088-2Emerging evidence shows that ubiquitination can occur on nonlysine residues and nonproteinaceous substrates. This perspective summarizes the recent …
Nature Chemical Biology, Published online: 25 July 2022; doi:10.1038/s41589-022-01087-3In the post-genomic era, many genes and regulatory elements remain uncharacterized, including riboswitches — RNA structures that control gene expres…
Nature Chemical Biology, Published online: 25 July 2022; doi:10.1038/s41589-022-01107-2Sensing the air
Nature Chemical Biology, Published online: 25 July 2022; doi:10.1038/s41589-022-01104-5Choosing the junk
Nature Chemical Biology, Published online: 25 July 2022; doi:10.1038/s41589-022-01106-3Altering the cap