Nature Chemical Biology, Published online: 29 September 2022; doi:10.1038/s41589-022-01133-0The gut microbiota has a key role in protecting hosts from pathogens. A new study identified a gut microbiota-derived bile acid (chenodeoxychol…
Nature Chemical Biology, Published online: 26 September 2022; doi:10.1038/s41589-022-01116-1DNA-templated compound library screening and structure-guided hit optimization resulted in the identification of selective macrocyclic inhibito…
Nature Chemical Biology, Published online: 26 September 2022; doi:10.1038/s41589-022-01137-wMukherjee et al. report that AcrIF24 is an Acr-Aca fusion protein that inhibits the Csy complex and suppresses transcription from the acrIF23–a…
Nature Chemical Biology, Published online: 26 September 2022; doi:10.1038/s41589-022-01139-8Cryo-EM structures of the mouse TRPV2 channel, combined with electrophysiology and simulations, reveal that endogenous cholesterol binds to the…
Nature Chemical Biology, Published online: 26 September 2022; doi:10.1038/s41589-022-01136-xAn INSPIRE platform for therapeutic regulators and sensors, based on split human domains binding physiological or clinically approved compounds…
Nature Chemical Biology, Published online: 18 August 2022; doi:10.1038/s41589-022-01084-6The description of the cryo-EM structure of an orphan adhesion GPCR–Gs protein complex in apo state facilitates the screening and identification o…
Nature Chemical Biology, Published online: 18 August 2022; doi:10.1038/s41589-022-01128-xUsing structural and biochemical methods, Liang et al. revealed a C-terminal glutamine-end recognition mechanism of TRIM7 E3 ligases, which enable…
Nature Chemical Biology, Published online: 16 August 2022; doi:10.1038/s41589-022-01129-wAuthor Correction: Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast
Nature Chemical Biology, Published online: 15 August 2022; doi:10.1038/s41589-022-01109-0A chemical genomics approach was used to identify regulators of drug sensitivity for pyrvinium, a cytotoxic agent with anti-cancer potential, reve…
Nature Chemical Biology, Published online: 15 August 2022; doi:10.1038/s41589-022-01091-7Metabolic labeling experiments on fermenting yeast revealed that ethanol is oxidized to acetaldehyde and acetyl-CoA and is also a major source of …