Nature Chemical Biology, Published online: 13 October 2022; doi:10.1038/s41589-022-01151-yPhase separation of androgen receptor underlies mutation-mediated antiandrogen resistance. A phenotypic screen enabled the discovery of ET516, wh…
Nature Chemical Biology, Published online: 13 October 2022; doi:10.1038/s41589-022-01150-zA small molecule was developed that disrupted the lipid–SH2 domain interaction of the spleen tyrosine kinase (Syk), suppressed oncogenic activiti…
Nature Chemical Biology, Published online: 13 October 2022; doi:10.1038/s41589-022-01117-0The structure of fungal sterol receptor Upc2 reveals ligand specificity and mechanism of transcriptional activation contributing to azole resista…
Nature Chemical Biology, Published online: 13 October 2022; doi:10.1038/s41589-022-01143-yThe fungal sterol receptor and transcription factor Upc2 activates the transcription of ergosterol biosynthesis genes in response to ergosterol d…
Nature Chemical Biology, Published online: 13 October 2022; doi:10.1038/s41589-022-01161-wProstate tumors, resistant to current antiandrogen therapies, represent a serious clinical challenge. A new report identifies androgen-receptor-d…
Nature Chemical Biology, Published online: 10 October 2022; doi:10.1038/s41589-022-01148-7Untargeted comparative metabolomics revealed serotonin biosynthesis and metabolism pathways in nonneuronal tissues that contribute to established…
Nature Chemical Biology, Published online: 10 October 2022; doi:10.1038/s41589-022-01152-xUnbiased metabolomics revealed the conversion of serotonin into N-acetylserotonin-derived glucosides by an intestinal carboxylesterase in Caenorh…
Nature Chemical Biology, Published online: 30 September 2022; doi:10.1038/s41589-022-01181-6Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine
Nature Chemical Biology, Published online: 29 September 2022; doi:10.1038/s41589-022-01149-6Aminoadamantane compounds, delivered to cells via binding to viroporin channels, induce S-nitrosylation of the ACE2 protein, inhibiting binding…
Nature Chemical Biology, Published online: 29 September 2022; doi:10.1038/s41589-022-01122-3Chemoproteomic analysis reveals that anti-infective bile acids directly bind and inactivate a transcriptional regulator of Salmonella virulence.