Nature Chemical Biology, Published online: 27 October 2022; doi:10.1038/s41589-022-01166-5Fan et al. report a potent and subtype-selective TRPV3 antagonist, Trpvicin, and reveal its binding sites and mode of action for TRPV3 inhibition…
Nature Chemical Biology, Published online: 27 October 2022; doi:10.1038/s41589-022-01170-9Velcrins kill cancer cells by inducing complex formation between PDE3A and SLFN12, upregulating SLFN12 RNase activity. Activated SLFN12 specifica…
Nature Chemical Biology, Published online: 24 October 2022; doi:10.1038/s41589-022-01159-4Mitochondrial ferredoxins FDX1 and FDX2 are assigned to specifically donate electrons to steroidogenesis, Fe–S protein biogenesis, heme a formati…
Nature Chemical Biology, Published online: 24 October 2022; doi:10.1038/s41589-022-01174-5Ferroptosis is a mechanism of cell death that has possible roles in numerous diseases. Two new studies have identified hydropersulfides as potent…
Nature Chemical Biology, Published online: 24 October 2022; doi:10.1038/s41589-022-01171-8Studies of the microbiome–host interaction are uncovering the metabolic mutual crosstalk between host tissues and gut microbiota. Hepatic glutami…
Nature Chemical Biology, Published online: 24 October 2022; doi:10.1038/s41589-022-01176-3Ferredoxins are universal electron donors. A study focusing on the two human mitochondrial ferredoxins reveals the existence of unique cellular f…
Nature Chemical Biology, Published online: 24 October 2022; doi:10.1038/s41589-022-01180-7YcaO enzymes are able to catalyze a diverse set of reactions and have found industrial applications. New biochemical data provide the first direc…
Nature Chemical Biology, Published online: 24 October 2022; doi:10.1038/s41589-022-01154-9Glutamine synthetase is the only enzyme that synthesizes glutamine in mammals. In vivo metabolomics showed that glutamine synthetase utilizes met…
Nature Chemical Biology, Published online: 24 October 2022; doi:10.1038/s41589-022-01141-0YcaO enzymes carry out diverse tailoring reactions of peptide-derived natural products, such as formation of rings and incorporation of sulfur, b…
Nature Chemical Biology, Published online: 20 October 2022; doi:10.1038/s41589-022-01187-0Releasing the safety CAR