Nature Chemical Biology, Published online: 04 September 2024; doi:10.1038/s41589-024-01720-3Cryo-electron microscopy and biochemical analysis reveal the activation mechanism of protein arginine kinase McsB by its activator McsA for pro…
Nature Chemical Biology, Published online: 03 September 2024; doi:10.1038/s41589-024-01714-1Development of a ligand-based proximity labeling strategy enables interrogation of the native cell membrane interactome for the GLP-1 receptor …
Nature Chemical Biology, Published online: 02 September 2024; doi:10.1038/s41589-024-01705-2Development of a biosensor for GPCR trafficking to the lysosome combined with a genome-wide CRISPR screen identified DNAJC13 as a critical regu…
Nature Chemical Biology, Published online: 02 September 2024; doi:10.1038/s41589-024-01699-xA method to study G-protein-coupled receptor (GPCR) trafficking has been developed using engineered APEX2 and CRISPR interference screening. Th…
Nature Chemical Biology, Published online: 30 August 2024; doi:10.1038/s41589-024-01722-1Organisms regulate biogenic crystal properties for various functions. Here the authors reveal the genetic and biochemical control of crystal morph…
Nature Chemical Biology, Published online: 30 August 2024; doi:10.1038/s41589-024-01721-2Pan et al. establish a general photoproximity labeling approach in living cells, applying microenvironment mapping with a HaloTag-based platform (…
Nature Chemical Biology, Published online: 30 August 2024; doi:10.1038/s41589-024-01719-wCao et al. introduce artificial lncRNA (alncRNA) for targeted protein degradation by engineering and linking lncRNA HOTAIR sequence to RNA aptamer…
Nature Chemical Biology, Published online: 30 August 2024; doi:10.1038/s41589-024-01716-zQiao and Nguyen et al. describe a strategy to block hypoxia-dependent gene expression in cell and mouse models of breast cancer through dual targe…
Nature Chemical Biology, Published online: 28 August 2024; doi:10.1038/s41589-024-01710-5Engineered demethylase LSD1 opens a new avenue in developing tools to study intricate relationships between histone post-translational modificatio…
Nature Chemical Biology, Published online: 28 August 2024; doi:10.1038/s41589-024-01732-zAuthor Correction: Balancing G protein selectivity and efficacy in the adenosine A2A receptor