Nature Chemical Biology

Nature Chemical Biology, Published online: 18 November 2022; doi:10.1038/s41589-022-01215-zSearching for a chaperone

Nature Chemical Biology, Published online: 17 November 2022; doi:10.1038/s41589-022-01192-3A membrane-tethering liquid–liquid phase-separation system was developed for programmable compartmentalization of cell-surface proteins and regu…

Nature Chemical Biology, Published online: 17 November 2022; doi:10.1038/s41589-022-01195-0Clustering and multimerization of cell surface proteins (CSPs) are essential for triggering downstream intracellular signaling events. Membrane-…

Nature Chemical Biology, Published online: 14 November 2022; doi:10.1038/s41589-022-01196-zSEUSS is a transcriptional adaptor that undergoes condensation after hyperosmotic stress-induced increase of molecular crowding. The SEUSS conde…

Nature Chemical Biology, Published online: 10 November 2022; doi:10.1038/s41589-022-01182-5The non-nucleoside reverse transcriptase inhibitors (NNRTIs) drive HIV protease-mediated CARD8 inflammasome activation, which is attenuated by d…

Nature Chemical Biology, Published online: 03 November 2022; doi:10.1038/s41589-022-01177-2Coupling haploid genetics with deep scanning mutagenesis, Hanzl et al. identified functional hotspots in E3 ubiquitin ligases that are selective…

Nature Chemical Biology, Published online: 31 October 2022; doi:10.1038/s41589-022-01172-7Coenzyme A (CoA) is a ubiquitous and essential cofactor. A biosensor for visualizing cytosolic and mitochondrial CoA in living cells was develope…

Nature Chemical Biology, Published online: 31 October 2022; doi:10.1038/s41589-022-01178-1Akizuki et al. reveal an unexpected role for K63-linked ubiquitin chains and the E2 enzyme UBE2N in degrader-induced degradation of cIAP1 through…

Nature Chemical Biology, Published online: 27 October 2022; doi:10.1038/s41589-022-01168-3Murray et al. identified and characterized a small-molecule inhibitor of human COQ8A, which belongs to the UbiB protein family and is essential f…

Nature Chemical Biology, Published online: 27 October 2022; doi:10.1038/s41589-022-01173-6The cryo-EM structures of MRGPRX1–Gq complexes are reported, which revealed the activation and allosteric modulation mechanism of human MRGPRX1 r…