Nature Chemical Biology, Published online: 02 January 2023; doi:10.1038/s41589-022-01223-zA machine-learning method called MetalNet was developed to systematically predict metal-binding sites in proteomes using sequence co-evolution, w…
Nature Chemical Biology, Published online: 02 January 2023; doi:10.1038/s41589-022-01220-2Heparan sulfate proteoglycans are extended disaccharide co-polymers containing decorations of sulfation and epimerization linked to cell surface …
Nature Chemical Biology, Published online: 28 December 2022; doi:10.1038/s41589-022-01218-wDiscovery of macrocyclic ligands to the 19S regulatory particle protein PSMD2 enables the synthesis of heterobifunctional molecules that demonst…
Nature Chemical Biology, Published online: 28 December 2022; doi:10.1038/s41589-022-01217-xSmall-molecule-mediated targeted protein degradation (TPD) relies on the recruitment of a target protein of interest to an E3 ligase. A new stud…
Nature Chemical Biology, Published online: 15 December 2022; doi:10.1038/s41589-022-01194-1This article presents a synthetic genetic program for orthogonal, tunable and programmable control of bacterial lifestyle and associated phase-s…
Nature Chemical Biology, Published online: 15 December 2022; doi:10.1038/s41589-022-01209-xMost engineered bacteria are designed to grow and function in a free-swimming state. A new method enables engineered bacteria to reversibly tran…
Nature Chemical Biology, Published online: 12 December 2022; doi:10.1038/s41589-022-01206-0The specificity constant of a promiscuous enzyme was raised by over 1,000-fold by using computational protein design to place a substrate recrui…
Nature Chemical Biology, Published online: 12 December 2022; doi:10.1038/s41589-022-01210-4A protein–protein interface between a peptide-recognition domain (Fyn-SH3) and catechol O-methyltransferase (COMT) is computationally designed t…
Nature Chemical Biology, Published online: 08 December 2022; doi:10.1038/s41589-022-01207-zA peptide display method was developed, revealing that a kinase important for infection by Salmonella and related pathogens detects specific hum…
Nature Chemical Biology, Published online: 05 December 2022; doi:10.1038/s41589-022-01198-xThe structure of SpoT assumes a compact τ-shaped structure in which the regulatory domains wrap around a core subdomain that controls the confor…