Nature Chemical Biology, Published online: 16 January 2023; doi:10.1038/s41589-022-01234-wDocking virtual libraries against protein structures has identified potent ligands for multiple targets. A comprehensive analysis reveals that th…
Nature Chemical Biology, Published online: 16 January 2023; doi:10.1038/s41589-022-01231-zCoupling selectivity was found to be partly lost with G proteins that bypass conformations that exist before GDP release, suggesting that selecti…
Nature Chemical Biology, Published online: 16 January 2023; doi:10.1038/s41589-022-01229-7A near-atomic resolution strain-specific cryo-EM structure of infectious prion fibrils from mice was determined, revealing a structural definitio…
Nature Chemical Biology, Published online: 16 January 2023; doi:10.1038/s41589-022-01230-0The authors present a framework for multiplexed optimization of metabolic pathways based on CRISPR–dCas12a-mediated genetic circuits, which can b…
Nature Chemical Biology, Published online: 12 January 2023; doi:10.1038/s41589-022-01224-yGuo et al. report a small molecule agonist of mitochondrial fusion that activates MFN1, an outer mitochondrial membrane protein, and protects cel…
Nature Chemical Biology, Published online: 12 January 2023; doi:10.1038/s41589-022-01240-yDNA damage results in the acetylation of the cell-cycle checkpoint kinase WEE1 at Lys177 enabling activation. The deacetylase SIRT1 directly asso…
Nature Chemical Biology, Published online: 12 January 2023; doi:10.1038/s41589-022-01225-xDevelopment of a quantitative approach to determine how far a signal from a cell travels as a diffusible molecule reveals a millimeter-scale quor…
Nature Chemical Biology, Published online: 12 January 2023; doi:10.1038/s41589-022-01227-9Development of a chemoproteomic platform to globally interrogate Fe–S cluster incorporation in a native proteome enables the elucidation of Fe–S …
Nature Chemical Biology, Published online: 12 January 2023; doi:10.1038/s41589-022-01238-6Analysis of cell–cell communication between embryonic stem cells using a combination of experiments and modeling shows that cells can communicate…
Nature Chemical Biology, Published online: 05 January 2023; doi:10.1038/s41589-022-01219-9Tryptophan C-mannosyltransferase (CMT) enzymes append a mannose to the first tryptophan of select sequences, which is important for the trafficki…