Nature Chemical Biology

Nature Chemical Biology, Published online: 31 January 2023; doi:10.1038/s41589-023-01261-1A passage for linkers

Nature Chemical Biology, Published online: 30 January 2023; doi:10.1038/s41589-022-01235-9Using single-molecule biophysics methods, Le et al. discovered that etoposide, a chemotherapeutic poison of topoisomerase II (topo II), promotes …

Nature Chemical Biology, Published online: 30 January 2023; doi:10.1038/s41589-022-01236-8Etoposide, a chemotherapeutic poison of type IIA eukaryotic topoisomerases (topo IIs), promotes topo II to compact DNA by trapping DNA loops, cre…

Nature Chemical Biology, Published online: 26 January 2023; doi:10.1038/s41589-022-01245-7A bifunctional amino acid, photo-ANA, equipped with a bio-orthogonal handle and a photoreactive warhead, specifically labels Salmonella spp. duri…

Nature Chemical Biology, Published online: 26 January 2023; doi:10.1038/s41589-022-01226-wThe multistep incorporation process of the catalytic NiFe(CN)2(CO) cofactor into [NiFe]-hydrogenase was deciphered by isolating key maturation in…

Nature Chemical Biology, Published online: 26 January 2023; doi:10.1038/s41589-022-01246-6A new biosynthetic core-forming enzyme, arginine cyclodipeptide synthase (RCDPS), was found to produce cyclo-arginine-Xaa dipeptides via a tRNA-d…

Nature Chemical Biology, Published online: 19 January 2023; doi:10.1038/s41589-022-01228-8Development of two bright light-up RNA systems with strong aptamer–dye interaction, high fluorogenicity, and remarkable photostability, enable si…

Nature Chemical Biology, Published online: 19 January 2023; doi:10.1038/s41589-022-01232-yThe F420-dependent sulfite reductase protects some methanogenic archaea by converting toxic sulfite. Structural analysis reveals how the two acti…

Nature Chemical Biology, Published online: 16 January 2023; doi:10.1038/s41589-022-01229-7A near-atomic resolution strain-specific cryo-EM structure of infectious prion fibrils from mice was determined, revealing a structural definitio…

Nature Chemical Biology, Published online: 16 January 2023; doi:10.1038/s41589-022-01230-0The authors present a framework for multiplexed optimization of metabolic pathways based on CRISPR–dCas12a-mediated genetic circuits, which can b…