Nature Chemical Biology

Nature Chemical Biology, Published online: 16 February 2023; doi:10.1038/s41589-022-01243-9To TnpB or not TnpB? Cas12 is the answer

Nature Chemical Biology, Published online: 16 February 2023; doi:10.1038/s41589-022-01242-wMis-annotation of TnpB: case of TaRGET-ABE

Nature Chemical Biology, Published online: 16 February 2023; doi:10.1038/s41589-022-01241-xSubstrate–inhibitor conjugation facilitates structural determination of the KDM2A/B-nucleosome complexes, which provides mechanistic insights in…

Nature Chemical Biology, Published online: 16 February 2023; doi:10.1038/s41589-023-01258-wAuthor Correction: Hypercompact adenine base editors based on a Cas12f variant guided by engineered RNA

Nature Chemical Biology, Published online: 16 February 2023; doi:10.1038/s41589-023-01266-wAuthor Correction: Voyage to minimal base editors

Nature Chemical Biology, Published online: 13 February 2023; doi:10.1038/s41589-022-01247-5The use of atomic-level simulations reveals a molecular mechanism by which a ligand can achieve selectivity between nearly identical receptors, …

Nature Chemical Biology, Published online: 13 February 2023; doi:10.1038/s41589-022-01253-7The function of a poorly characterized transmembrane protein, TMEM164, was annotated by integrated genetic dependency mapping, AlphaFold2 struct…

Nature Chemical Biology, Published online: 13 February 2023; doi:10.1038/s41589-023-01255-zA crucial step in the cell-death process of ferroptosis is the incorporation of free polyunsaturated fatty acids (PUFAs) into membrane phospholi…

Nature Chemical Biology, Published online: 09 February 2023; doi:10.1038/s41589-023-01265-xBrain imaging using the compact NanoLuc luciferase has been stymied by the lack of suitable substrates. Su et al. report a brain-optimized subst…

Nature Chemical Biology, Published online: 06 February 2023; doi:10.1038/s41589-022-01250-wFerroptosis can be induced by lipid peroxidation in various subcellular membranes, including the endoplasmic reticulum (ER), mitochondria and ly…