Nature Chemical Biology, Published online: 25 September 2024; doi:10.1038/s41589-024-01734-xA nanopore-based framework distinguishes and quantifies tyrosine sulfation from phosphorylation in peptide mixtures and native protein fragment…
Nature Chemical Biology, Published online: 24 September 2024; doi:10.1038/s41589-024-01730-1An automation tool has been designed that enables partitioning of an algorithm into subcircuits split across cells for biological computing. Th…
Nature Chemical Biology, Published online: 24 September 2024; doi:10.1038/s41589-024-01728-9The integration of a new orthogonal redox cofactor opens opportunities for controlling reaction equilibria. Because it does not interfere with …
Nature Chemical Biology, Published online: 23 September 2024; doi:10.1038/s41589-024-01731-0The use of an adenine base editor enables identification of functional serine, threonine and tyrosine residues that impact cell fitness on a ge…
Nature Chemical Biology, Published online: 20 September 2024; doi:10.1038/s41589-024-01739-6Research in the early days of chemical biology was mostly limited to the application of chemical tools to model cell lines grown in incubators….
Nature Chemical Biology, Published online: 19 September 2024; doi:10.1038/s41589-024-01715-0Orally bioavailable, high molecular weight macrocyclic peptides that inhibit difficult-to-drug protein–protein interactions are of high therape…
Nature Chemical Biology, Published online: 19 September 2024; doi:10.1038/s41589-024-01729-8Li, Cheng, Yu and colleagues have discovered a Cas13j family, including the compact and highly efficient LepCas13j (529 aa) and ChiCas13j (424 …
Nature Chemical Biology, Published online: 19 September 2024; doi:10.1038/s41589-024-01726-xA tRNA modification, named 2-aminovaleramididine (ava2C), has been discovered in plant organelles and bacteria. Structural analysis shows speci…
Nature Chemical Biology, Published online: 18 September 2024; doi:10.1038/s41589-024-01738-7Development of a paralog-hopping approach leveraging chemical proteomic data on covalently liganded cysteines revealed an allosteric pocket sha…
Nature Chemical Biology, Published online: 18 September 2024; doi:10.1038/s41589-024-01746-7Sweet RNA