Nature Chemical Biology, Published online: 17 October 2024; doi:10.1038/s41589-024-01752-9The paenilamicins are hybrid nonribosomal peptide–polyketide compounds that inhibit protein synthesis. Here the authors reveal that paenilamicins…
Nature Chemical Biology, Published online: 16 October 2024; doi:10.1038/s41589-024-01741-yDevelopment of a targeted protein degradation platform, methylarginine targeting chimera (MrTAC), enables arginine methylation-driven degradation…
Nature Chemical Biology, Published online: 16 October 2024; doi:10.1038/s41589-024-01748-5Fucosylation of host glycoproteins is revealed to sensitize cells to cholera intoxication while fucosylation of host glycolipids is protective. T…
Nature Chemical Biology, Published online: 15 October 2024; doi:10.1038/s41589-024-01743-wProkaryotic CRISPR–Cas systems are counteracted by phage-encoded anti-CRISPR elements, and how they protect themselves remains enigmatic. A study…
Nature Chemical Biology, Published online: 14 October 2024; doi:10.1038/s41589-024-01759-2Metabolic engineering often suffers from competition between heterologous enzymes and native metabolism. Here the authors improve on a strategy o…
Nature Chemical Biology, Published online: 11 October 2024; doi:10.1038/s41589-024-01758-3Protein kinase C (PKC) enzymes are critical signaling molecules but their regulation at emerging signaling hubs is unclear. Here Su et al. develo…
Nature Chemical Biology, Published online: 11 October 2024; doi:10.1038/s41589-024-01750-xUsing site-specific chemical crosslinking strategies, Ai, Tong and Deng et al. captured structural intermediates of ubiquitin E3 ligase RNF168-me…
Nature Chemical Biology, Published online: 11 October 2024; doi:10.1038/s41589-024-01742-xHigh levels of superoxide (O2•–) are known to regulate plant stem cell behavior, but its downstream effectors remain unclear. O2•– was found to d…
Nature Chemical Biology, Published online: 30 September 2024; doi:10.1038/s41589-024-01740-zBiofouling causes a huge economic loss to our society. This Perspective examines the biofouling process from microfouling to macrofouling, disc…
Nature Chemical Biology, Published online: 26 September 2024; doi:10.1038/s41589-024-01717-yThis Perspective discusses how macromolecular condensation can regulate the electrochemistry to affect biological function in living cells and …