Nature Chemical Biology, Published online: 29 October 2024; doi:10.1038/s41589-024-01757-4In May 2024, ‘Protein Degradation in Focus’, a special symposium aimed at bringing together scientists in the targeted protein degradation (TPD) …
Nature Chemical Biology, Published online: 28 October 2024; doi:10.1038/s41589-024-01756-51,3-Pr2-6-OTs GlcNAlk is a precursor uniquely targeting the essential glycosyltransferase MGAT1 to selectively tag hybrid N-glycan-modified prote…
Nature Chemical Biology, Published online: 28 October 2024; doi:10.1038/s41589-024-01765-4The mechanism underlying the formation of crystals in cells is not completely understood. An article now reports on the biochemical control of th…
Nature Chemical Biology, Published online: 24 October 2024; doi:10.1038/s41589-024-01760-9A cysteine-reactive degrader of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 14 (nsp14) was identified, whi…
Nature Chemical Biology, Published online: 24 October 2024; doi:10.1038/s41589-024-01749-4Covalent modification of cysteine by electrophilic small molecules enables broad targeting of the unliganded proteome. A study reveals that cyste…
Nature Chemical Biology, Published online: 24 October 2024; doi:10.1038/s41589-024-01755-6Characterization of the heterogeneity in the glycosylation of biotherapeutics is crucial for drug development but challenging. Now, an approach a…
Nature Chemical Biology, Published online: 23 October 2024; doi:10.1038/s41589-024-01763-6Application of synthetic glycan (SG) preparations in gnotobiotic mice colonized with a defined bacterial community composed of members of the hum…
Nature Chemical Biology, Published online: 22 October 2024; doi:10.1038/s41589-024-01753-8Cryo-electron microscopy structures of paenilamicin-stalled ribosomes showed that it has a unique ribosome-binding site located between the A- an…
Nature Chemical Biology, Published online: 22 October 2024; doi:10.1038/s41589-024-01768-1Studying ATP synthesis in situ
Nature Chemical Biology, Published online: 22 October 2024; doi:10.1038/s41589-024-01744-9Arginine methylation acts as a signal for intracellular proteins to be degraded in lysosomes. We developed methylarginine targeting chimera (MrTA…