Nature Chemical Biology
Assembly-activated aggregation
Nature Chemical Biology, Published online: 18 November 2024; doi:10.1038/s41589-024-01785-0Assembly-activated aggregation
Nature Chemical Biology
A key to sperm–egg union
Nature Chemical Biology, Published online: 18 November 2024; doi:10.1038/s41589-024-01787-yA key to sperm–egg union
Nature Chemical Biology
Open-ended molecular recording of sequential cellular events into DNA
Nature Chemical Biology, Published online: 14 November 2024; doi:10.1038/s41589-024-01764-5Loveless, Carlson and colleagues describe peCHYRON, a DNA recorder that propagates an unending chain of insertions. Each link contains a randomi…
Nature Chemical Biology
Spatiotemporal control of subcellular <i>O</i>-GlcNAc signaling using Opto-OGT
Nature Chemical Biology, Published online: 14 November 2024; doi:10.1038/s41589-024-01770-7An optogenetic tool called Opto-OGT has been developed that enables researchers to probe pathways involving modifications with O-linked β-N-acet…
Nature Chemical Biology
Author Correction: Evybactin is a DNA gyrase inhibitor that selectively kills <i>Mycobacterium tuberculosis</i>
Nature Chemical Biology, Published online: 08 November 2024; doi:10.1038/s41589-024-01779-yAuthor Correction: Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis
Nature Chemical Biology
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway
Nature Chemical Biology, Published online: 08 November 2024; doi:10.1038/s41589-024-01784-1Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway
Nature Chemical Biology
Engineering a xylose fermenting yeast for lignocellulosic ethanol production
Nature Chemical Biology, Published online: 04 November 2024; doi:10.1038/s41589-024-01771-6The sodium salts in corn stover hydrolysates have been identified as important inhibitors for cellulosic ethanol production. Adaptive evolution …
Nature Chemical Biology
Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion
Nature Chemical Biology, Published online: 31 October 2024; doi:10.1038/s41589-024-01762-7A compound screen using zebrafish identified carbonic anhydrase (CA) as a modulator of tau toxicity. CA inhibition abrogates lysosomal acidificat…
Nature Chemical Biology
A multiplex single-cell RNA-Seq pharmacotranscriptomics pipeline for drug discovery
Nature Chemical Biology, Published online: 31 October 2024; doi:10.1038/s41589-024-01761-8A high-throughput precision oncology pipeline for pharmacotranscriptomic profiling using live-cell barcoding and single-cell RNA sequencing was d…
Nature Chemical Biology
Evading resistance at the double
Nature Chemical Biology, Published online: 30 October 2024; doi:10.1038/s41589-024-01772-5Synthesis and characterization of new macrolones — fusions of two antibiotic classes with distinct bacterial targets — reveal the basis for their…