Nature Chemical Biology, Published online: 31 May 2024; doi:10.1038/s41589-024-01631-3We developed a rational approach to design peptide-based covalent inhibitors and coupled the inhibitors with antibodies for cell-specific delivery. W…
Nature Chemical Biology, Published online: 30 May 2024; doi:10.1038/s41589-024-01632-2Jiang et al. developed a computational method to design repeat proteins with multiple structured loops that are buttressed by extensive hydrogen bond…
Nature Chemical Biology, Published online: 30 May 2024; doi:10.1038/s41589-024-01633-1Huang et al. report the tertiary structure of a small monomeric fluorogenic RNA aptamer named Clivia, characterized by a large Stokes shift, revealin…
Nature Chemical Biology, Published online: 29 May 2024; doi:10.1038/s41589-024-01627-zCathepsins are relevant therapeutic targets in cancer and other diseases. Here, the authors developed a different approach to block the activity of c…
Nature Chemical Biology, Published online: 28 May 2024; doi:10.1038/s41589-024-01634-0The ZDHHC family of palmitoyl transferases lipidates numerous protein targets, but the paucity of selective inhibitors has hindered their target prof…
Nature Chemical Biology, Published online: 23 May 2024; doi:10.1038/s41589-024-01628-yEngineered living materials harness the computational power of biology to control interesting material properties. Here the authors leverage complex …
Nature Chemical Biology, Published online: 23 May 2024; doi:10.1038/s41589-024-01629-xZuo et al. developed a highly bright and stable green fluorescent RNA for robust imaging of the dynamics of messenger RNA in living cells, enabling v…
Nature Chemical Biology, Published online: 23 May 2024; doi:10.1038/s41589-024-01624-2Targeted protein degradation has emerged as a promising approach in drug discovery, harnessing a cell’s intrinsic machinery to eliminate disease-rela…
Nature Chemical Biology, Published online: 21 May 2024; doi:10.1038/s41589-024-01621-5Yin et al. discover that the phosphatase PTENα acts as an RNA-binding protein, mitigating viral-induced inflammation in the brain by constraining RIG…
Nature Chemical Biology, Published online: 21 May 2024; doi:10.1038/s41589-024-01618-0Owens et al. reported PFI-7, a selective and potent antagonist of GID4 of the CTLH E3 ligase complex, which enables identification of human GID4 targ…