Nature Chemical Biology, Published online: 04 July 2024; doi:10.1038/s41589-024-01666-6A major bottleneck of targeted protein degradation (TPD) has been the discovery of E3 ligases that are amenable to this strategy. Two new studies hi…
Nature Chemical Biology, Published online: 02 July 2024; doi:10.1038/s41589-024-01658-6Peptides are fundamental in life and are widely used as therapeutic agents; however, they are problematic to produce by chemical synthesis. The disc…
Nature Chemical Biology, Published online: 01 July 2024; doi:10.1038/s41589-024-01664-8The enzymes that link bacterial capsule polymers to the outermembrane glycolipids, termed transition transferases, are identified, enabling reconstr…
Nature Chemical Biology, Published online: 01 July 2024; doi:10.1038/s41589-024-01657-7Total in vitro biosynthesis can reveal unusual pathways evolved by nature to produce natural products. Here the authors report on enzymatic cascades…
Nature Chemical Biology, Published online: 28 June 2024; doi:10.1038/s41589-024-01651-zKeratinicyclins are recently discovered glycopeptide antibiotics. Now, the mechanism of action of keratinicyclin B has been uncovered. Keratinicycli…
Nature Chemical Biology, Published online: 28 June 2024; doi:10.1038/s41589-024-01644-yThe non-enzymatic nature of protein glycation makes it a complicated modification to study. This review focuses on the chemistry of glycation, highl…
Nature Chemical Biology, Published online: 27 June 2024; doi:10.1038/s41589-024-01662-wVersatile methods for rapid, reversible and repetitive control of protein localization are lacking. A novel optically controlled dimerization system…
Nature Chemical Biology, Published online: 24 June 2024; doi:10.1038/s41589-024-01675-5On the quest for mescaline
Nature Chemical Biology, Published online: 24 June 2024; doi:10.1038/s41589-024-01674-6A direct hit
Nature Chemical Biology, Published online: 24 June 2024; doi:10.1038/s41589-024-01676-4Identifying p53-independent apoptosis