Nature Chemical Biology, Published online: 08 July 2024; doi:10.1038/s41589-024-01669-3Through rational protein engineering and structure-guided ωRNA engineering, the ωRNA-guided endonuclease IscB system was developed into a highly eff…
Nature Chemical Biology, Published online: 08 July 2024; doi:10.1038/s41589-024-01659-5The ICP1 (International Center for Diarrheal Disease Research, Bangladesh cholera phage 1) clustered regularly interspaced short palindromic repeats…
Nature Chemical Biology, Published online: 08 July 2024; doi:10.1038/s41589-024-01670-wBy engineering a tiny OgeuIscB–ωRNA system and tethering DNA-binding protein Sso7d, the authors developed robust miniature base editors SIminiBEs, w…
Nature Chemical Biology, Published online: 08 July 2024; doi:10.1038/s41589-024-01677-3Time-resolved synthesis of target proteins via proximity-triggered protein trans-splicing has now been shown to enable the activation of a diverse s…
Nature Chemical Biology, Published online: 08 July 2024; doi:10.1038/s41589-024-01667-5In type I-F CRISPR–Cas systems, Cas2/3 is typically recruited to the interference complex Cascade by Cas8f. We resolved the structures of the phage …
Nature Chemical Biology, Published online: 05 July 2024; doi:10.1038/s41589-024-01673-7RNA-based genetic regulation has been used to control protein translation in synthetic cells in response to the external temperature. RNA thermomete…
Nature Chemical Biology, Published online: 05 July 2024; doi:10.1038/s41589-024-01661-xYan and Tang developed a CRISPR-based RNA-editing approach called DECOR by fusing a Cas13 variant to an evolved E. coli tRNA adenosine deaminase, Ta…
Nature Chemical Biology, Published online: 04 July 2024; doi:10.1038/s41589-024-01666-6A major bottleneck of targeted protein degradation (TPD) has been the discovery of E3 ligases that are amenable to this strategy. Two new studies hi…
Nature Chemical Biology, Published online: 04 July 2024; doi:10.1038/s41589-024-01660-yNie et al. describe a mechanism underlying the degradation of the histone methyltransferase NSD2 through the recruitment of FBXO22 E3 ligase, provid…
Nature Chemical Biology, Published online: 04 July 2024; doi:10.1038/s41589-024-01655-9Basu et al. report a clustered regularly interspaced short palindromic repeats (CRISPR)-based transcriptional activation screen method for the disco…