Nature Chemical Biology, Published online: 25 July 2024; doi:10.1038/s41589-024-01701-6We combine RNA thermometer genetic switches, cell-free protein expression and synthetic cell design to create cell-sized systems that can initiate t…
Nature Chemical Biology, Published online: 23 July 2024; doi:10.1038/s41589-024-01681-7Soapwort (Saponaria officinalis) is a rich reservoir of triterpenoid glycosides that often have important pharmaceutical, nutraceutical and agronomi…
Nature Chemical Biology, Published online: 22 July 2024; doi:10.1038/s41589-024-01685-3Hybrids of macrolides and quinolones, called macrolones, can overcome macrolide-induced resistance through new interactions between the quinolone mo…
Nature Chemical Biology, Published online: 22 July 2024; doi:10.1038/s41589-024-01683-5SMAD ubiquitylation regulatory factor 1 (Smurf1) was identified as a critical activator of the phosphoinositide 3-kinase (PI3K)–Akt pathway by promo…
Nature Chemical Biology, Published online: 19 July 2024; doi:10.1038/s41589-024-01680-8Using a combination of antibody- and LC–MS/MS-based methods, Zhang et al. reveal lysine l-lactylation as the key lactylation isomer in cellular hist…
Nature Chemical Biology, Published online: 19 July 2024; doi:10.1038/s41589-024-01679-1This Perspective discusses the application of algorithmic methods throughout the preclinical phases of drug discovery to accelerate initial hit disc…
Nature Chemical Biology, Published online: 19 July 2024; doi:10.1038/s41589-024-01687-1The field of engineered living materials (ELMs) involves incorporating cells into materials to enable new functionalities. Now, ELMs have been devel…
Nature Chemical Biology, Published online: 15 July 2024; doi:10.1038/s41589-024-01672-8Protein misfolding can spread from one molecule to another in infectious prion diseases. The propagation of protein misfolding has been directly obs…
Nature Chemical Biology, Published online: 10 July 2024; doi:10.1038/s41589-024-01663-9Biological reduction of dinitrogen by nitrogenase requires high-energy electrons to form ammonium ion. A new study reveals the structure and functio…
Nature Chemical Biology, Published online: 09 July 2024; doi:10.1038/s41589-024-01665-7González-Delgado et al. developed retron-based editors termed multitrons, which can modify multiple sites on a single genome simultaneously. This te…