Nature Chemical Biology, Published online: 06 March 2025; doi:10.1038/s41589-025-01858-8Two mGlu3–βarr1 cryo-EM structures with 2:1 and 2:2 stoichiometries are reported, revealing that the inactive state involves mGlu3 engagement of βa…
Nature Chemical Biology, Published online: 04 March 2025; doi:10.1038/s41589-025-01851-1A new study reveals that the RAF isoform ARAF uniquely forms solid-like granules at the cell membrane that have a key role in regulating RAS activa…
Nature Chemical Biology, Published online: 03 March 2025; doi:10.1038/s41589-025-01850-2O-fucosylation, a type of protein glycosylation, uniquely occurs on specific protein domains, including the EGF domain in Notch. FUT10 and FUT11, e…
Nature Chemical Biology, Published online: 26 February 2025; doi:10.1038/s41589-025-01865-9Publisher Correction: Visualizing drug effects over time in live animals using optical pharmacodynamics
Nature Chemical Biology, Published online: 25 February 2025; doi:10.1038/s41589-025-01855-xTurning down the heat
Nature Chemical Biology, Published online: 25 February 2025; doi:10.1038/s41589-025-01854-yGuiding generative AI
Nature Chemical Biology, Published online: 25 February 2025; doi:10.1038/s41589-025-01856-wSmall molecules deliver big
Nature Chemical Biology, Published online: 20 February 2025; doi:10.1038/s41589-025-01849-9Wang et al. develop data-independent acquisition activity-based protein profiling, a quantitative chemoproteomic method to globally profile prot…
Nature Chemical Biology, Published online: 19 February 2025; doi:10.1038/s41589-025-01853-zThe small molecule Ebio3 inactivates the ‘non-inactivating’ potassium channel KCNQ2. This inhibition occurs by a unique ‘squeeze-to-inhibit’ mec…
Nature Chemical Biology, Published online: 18 November 2024; doi:10.1038/s41589-024-01786-zGuiding the pioneer