Nature Chemical Biology, Published online: 04 November 2024; doi:10.1038/s41589-024-01771-6The sodium salts in corn stover hydrolysates have been identified as important inhibitors for cellulosic ethanol production. Adaptive evolution …
Nature Chemical Biology, Published online: 31 October 2024; doi:10.1038/s41589-024-01762-7A compound screen using zebrafish identified carbonic anhydrase (CA) as a modulator of tau toxicity. CA inhibition abrogates lysosomal acidificat…
Nature Chemical Biology, Published online: 31 October 2024; doi:10.1038/s41589-024-01761-8A high-throughput precision oncology pipeline for pharmacotranscriptomic profiling using live-cell barcoding and single-cell RNA sequencing was d…
Nature Chemical Biology, Published online: 30 October 2024; doi:10.1038/s41589-024-01772-5Synthesis and characterization of new macrolones — fusions of two antibiotic classes with distinct bacterial targets — reveal the basis for their…
Nature Chemical Biology, Published online: 29 October 2024; doi:10.1038/s41589-024-01757-4In May 2024, ‘Protein Degradation in Focus’, a special symposium aimed at bringing together scientists in the targeted protein degradation (TPD) …
Nature Chemical Biology, Published online: 28 October 2024; doi:10.1038/s41589-024-01756-51,3-Pr2-6-OTs GlcNAlk is a precursor uniquely targeting the essential glycosyltransferase MGAT1 to selectively tag hybrid N-glycan-modified prote…
Nature Chemical Biology, Published online: 28 October 2024; doi:10.1038/s41589-024-01765-4The mechanism underlying the formation of crystals in cells is not completely understood. An article now reports on the biochemical control of th…
Nature Chemical Biology, Published online: 24 October 2024; doi:10.1038/s41589-024-01749-4Covalent modification of cysteine by electrophilic small molecules enables broad targeting of the unliganded proteome. A study reveals that cyste…
Nature Chemical Biology, Published online: 24 October 2024; doi:10.1038/s41589-024-01755-6Characterization of the heterogeneity in the glycosylation of biotherapeutics is crucial for drug development but challenging. Now, an approach a…
Nature Chemical Biology, Published online: 24 October 2024; doi:10.1038/s41589-024-01760-9A cysteine-reactive degrader of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 14 (nsp14) was identified, whi…