Nature Chemical Biology, Published online: 04 April 2025; doi:10.1038/s41589-025-01866-8Native top-down proteomics reveals epidermal growth factor receptor–estrogen receptor-alpha (EGFR–ER) signaling crosstalk in breast cancer cells an…
Nature Chemical Biology, Published online: 02 April 2025; doi:10.1038/s41589-025-01867-7Evaluating the off-target effect is crucial for ensuring the safety of CRISPR–Cas9-based technologies. Duan, Gao and Zhang et al. developed TOPO-se…
Nature Chemical Biology, Published online: 31 March 2025; doi:10.1038/s41589-025-01868-6A method called UltraSelex for identifying RNA aptamers has been developed. UltraSelex is noniterative and can combine biochemical partitioning, hi…
Nature Chemical Biology, Published online: 28 March 2025; doi:10.1038/s41589-025-01872-wZhang, Mille-Fragoso and colleagues developed a synthetic receptor platform named LIDAR (Ligand-Induced Dimerization-Activating RNA editing), which…
Nature Chemical Biology, Published online: 28 March 2025; doi:10.1038/s41589-025-01892-6Author Correction: Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA
Nature Chemical Biology, Published online: 27 March 2025; doi:10.1038/s41589-025-01871-xTrans-splicing enables the ligation of exons from different pre-mRNAs into a single transcript. A recent study harnesses this process and develops …
Nature Chemical Biology, Published online: 26 March 2025; doi:10.1038/s41589-025-01869-5Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybu…
Nature Chemical Biology, Published online: 25 March 2025; doi:10.1038/s41589-025-01863-xThe authors developed a small molecule targeting the circadian regulator BMAL1, enabling dose-dependent modulation of gene expression for circadian…
Nature Chemical Biology, Published online: 24 March 2025; doi:10.1038/s41589-025-01876-6Guiding chemoenzymatic synthesis
Nature Chemical Biology, Published online: 24 March 2025; doi:10.1038/s41589-025-01875-7Phage-fueled defense system