Molecular Cell
Base editor screens for <em>in situ</em> mutational scanning at scale
Publication date: Available online 29 June 2023Source: Molecular CellAuthor(s): Nicholas Z. Lue, Brian B. Liau
Molecular Cell
Glucose-induced CRL4<sup>COP1</sup>-p53 axis amplifies glycometabolism to drive tumorigenesis
Publication date: Available online 29 June 2023Source: Molecular CellAuthor(s): Yang Su, Yifan Luo, Peitao Zhang, Hong Lin, Weijie Pu, Hongyun Zhang, Huifang Wang, Yi Hao, Yihang Xiao, Xiaozhe Zhang, Xiayun Wei, Siyue Nie, Keren Zhang, Qiuyu Fu, Hao Ch…
Molecular Cell
Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel
Publication date: Available online 29 June 2023Source: Molecular CellAuthor(s): Jiyuan Zhang, Weizhong Zeng, Yan Han, Wan-Ru Lee, Jen Liou, Youxing Jiang
Molecular Cell
A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy
Publication date: Available online 26 June 2023Source: Molecular CellAuthor(s): Brittany A. Townley, Luke Buerer, Ning Tsao, Albino Bacolla, Fadhel Mansoori, Timur Rusanov, Nathanial Clark, Negar Goodarzi, Nicolas Schmidt, Sridhar Nonavinkere Srivatsan…
Molecular Cell
Convergence of multiple RNA-silencing pathways on GW182/TNRC6
Publication date: Available online 26 June 2023Source: Molecular CellAuthor(s): Thomas Welte, Alison Goulois, Michael B. Stadler, Daniel Hess, Charlotte Soneson, Anca Neagu, Chiara Azzi, Marlena J. Wisser, Jan Seebacher, Isabel Schmidt, David Estoppey,…
Molecular Cell
Structural insights into human co-transcriptional capping
Publication date: Available online 26 June 2023Source: Molecular CellAuthor(s): Gaurika Garg, Christian Dienemann, Lucas Farnung, Juliane Schwarz, Andreas Linden, Henning Urlaub, Patrick Cramer
Molecular Cell
Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner
Publication date: Available online 21 June 2023Source: Molecular CellAuthor(s): Meng Wang, Laura T.L. Brandt, Xiaonan Wang, Holly Russell, Emily Mitchell, Ashley N. Kamimae-Lanning, Jill M. Brown, Felix A. Dingler, Juan I. Garaycoechea, Tomoya Isobe, S…
Molecular Cell
Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment
Publication date: Available online 20 June 2023Source: Molecular CellAuthor(s): Ning Cui, Jun-Tao Zhang, Yongrui Liu, Yanhong Liu, Xiao-Yu Liu, Chongyuan Wang, Hongda Huang, Ning Jia
Molecular Cell
Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange
Publication date: Available online 19 June 2023Source: Molecular CellAuthor(s): Mohammed Shaaban, Julie A. Clapperton, Shan Ding, Simone Kunzelmann, Märt-Erik Mäeots, Sarah L. Maslen, J. Mark Skehel, Radoslav I. Enchev
Molecular Cell
A restrictor complex of ZC3H4, WDR82, and ARS2 integrates with PNUTS to control unproductive transcription
Publication date: Available online 16 June 2023Source: Molecular CellAuthor(s): Chris Estell, Lee Davidson, Joshua D. Eaton, Hiroshi Kimura, Vicki A.M. Gold, Steven West