Immunology
Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammation
Interleukin 34 (IL34) and colony-stimulating factor 1 (CSF1) signal through a shared receptor (CSF1R) to control macrophage survival, differentiation, and function. Here, we describe the impact of loss-of-function mutation in the rat Il34 gene. In con…
Immunology
Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammation
Interleukin 34 (IL34) and colony-stimulating factor 1 (CSF1) signal through a shared receptor (CSF1R) to control macrophage survival, differentiation, and function. Here, we describe the impact of loss-of-function mutation in the rat Il34 gene. In con…
Immunology
FGF7 as an essential mediator for the onset of ankylosing enthesitis related to psoriatic dermatitis
IL-17A plays an important role in the pathology of psoriasis and psoriatic arthritis (PsA). However, the pathogenic association between the skin and joint manifestations in PsA is not completely understood. In this study, we initially observed that IL…
Immunology
Antigen-specific modulation of chronic experimental autoimmune encephalomyelitis in humanized mice by TCR-like antibody targeting autoreactive T-cell epitope
The development and application of human TCR-like (TCRL) antibodies recognizing disease-specific MHC–peptide complexes may prove as an important tool for basic research and therapeutic applications. Multiple sclerosis is characterized …
Immunology
Antigen-specific modulation of chronic experimental autoimmune encephalomyelitis in humanized mice by TCR-like antibody targeting autoreactive T-cell epitope
The development and application of human TCR-like (TCRL) antibodies recognizing disease-specific MHC–peptide complexes may prove as an important tool for basic research and therapeutic applications. Multiple sclerosis is characterized …
Immunology
Antigen-specific modulation of chronic experimental autoimmune encephalomyelitis in humanized mice by TCR-like antibody targeting autoreactive T-cell epitope
The development and application of human TCR-like (TCRL) antibodies recognizing disease-specific MHC–peptide complexes may prove as an important tool for basic research and therapeutic applications. Multiple sclerosis is characterized …
Immunology
Antigen-specific modulation of chronic experimental autoimmune encephalomyelitis in humanized mice by TCR-like antibody targeting autoreactive T-cell epitope
The development and application of human TCR-like (TCRL) antibodies recognizing disease-specific MHC–peptide complexes may prove as an important tool for basic research and therapeutic applications. Multiple sclerosis is characterized …
Immunology
SNX5 promotes antigen presentation in B cells by dual regulation of actin and lysosomal dynamics
B cells rapidly adapt their endocytic pathway to promote the uptake and processing of extracellular antigens recognized through the B-cell receptor (BCR). The mechanisms coupling changes in endomembrane trafficking to the capacity of B cells to screen…
Immunology
SNX5 promotes antigen presentation in B cells by dual regulation of actin and lysosomal dynamics
B cells rapidly adapt their endocytic pathway to promote the uptake and processing of extracellular antigens recognized through the B-cell receptor (BCR). The mechanisms coupling changes in endomembrane trafficking to the capacity of B cells to screen…