Cancer Biology
Distinct states of nucleolar stress induced by anticancer drugs
Ribosome biogenesis is a vital and highly energy-consuming cellular function occurring primarily in the nucleolus. Cancer cells have an elevated demand for ribosomes to sustain continuous proliferation. This study evaluated the impact of existing antic…
Cancer Biology
Treatment with tumor-treating fields (TTFields) suppresses intercellular tunneling nanotube formation in vitro and upregulates immuno-oncologic biomarkers in vivo in malignant mesothelioma
Disruption of intercellular communication within tumors is emerging as a novel potential strategy for cancer-directed therapy. Tumor-Treating Fields (TTFields) therapy is a treatment modality that has itself emerged over the past decade in active clini…
Cancer Biology
Identification of CD133<sup>+</sup> intercellsomes in intercellular communication to offset intracellular signal deficit
CD133 (prominin 1) is widely viewed as a cancer stem cell marker in association with drug resistance and cancer recurrence. Herein, we report that with impaired RTK-Shp2-Ras-Erk signaling, heterogenous hepatocytes form clusters that manage to divide du…
Cancer Biology
Protecting the heart
Blocking a protein known as EPAC1 may prevent the development of heart-related side effects caused by a chemotherapy drug.
Cancer Biology
<i>FOXP2</i> confers oncogenic effects in prostate cancer
Identification oncogenes is fundamental to revealing the molecular basis of cancer. Here, we found that FOXP2 is overexpressed in human prostate cancer cells and prostate tumors, but its expression is absent in normal prostate epithelial cells and low …
Cancer Biology
EPAC1 inhibition protects the heart from doxorubicin-induced toxicity
Anthracyclines, such as doxorubicin (Dox), are widely used chemotherapeutic agents for the treatment of solid tumors and hematologic malignancies. However, they frequently induce cardiotoxicity leading to dilated cardiomyopathy and heart failure. This …
Cancer Biology
Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells
Mannose has anticancer activity that inhibits cell proliferation and enhances the efficacy of chemotherapy. How mannose exerts its anticancer activity, however, remains poorly understood. Here, using genetically engineered human cancer cells that permi…
Cancer Biology
How nearby nutrients shape tumor growth
Studying the nutrient composition immediately surrounding pancreatic cancer cells provides new insights into their metabolic properties and how they can evade the immune system to promote disease progression.