Bioorganic Chemistry

Scopariusicides D–M, ent-clerodane-based isomeric meroditerpenoids with a cyclobutane-fused γ/δ-lactone core from Isodon scoparius

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Xing-Ren Li, Kun Hu, Bing-Chao Yan, Xiao-Nian Li, Han-Dong Sun, Yang Liu, Pema-Tenzin Puno

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Wei-Xiao Niu, Yun-Yang Bao, Na Zhang, Zhen-Ning Lu, Mao-Xu Ge, Yi-Ming Li, Yi Li, Ming-Hua Chen, Hong-Wei He

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Design, synthesis and biological evaluation of N-(4-alkoxy-3-(1H-tetrazol-1-yl)phenyl) heterocyclic aromatic amide derivatives as xanthine oxidase inhibitors

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Ting-jian Zhang, Zhen-hao Zhang, Xu Zhang, Zhao-ran Wang, En-yu Xu, Shun Tu, Yi Zhang, Fan-hao Meng

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Six pairs of enantiomeric phthalide dimers from the rhizomes of Ligusticum chuanxiong and their absolute configurations and anti-inflammatory activities

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Lu Huang, Cheng Peng, Li Guo, Rui Feng, Hong-Zhen Shu, Yun-Cai Tian, Qin-Mei Zhou, Liang Xiong

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Design, synthesis and biological evaluation of a series of novel pyrrolo[2,3-d]pyrimidin/pyrazolo[3,4-d]pyrimidin-4-amine derivatives as FGFRs-dominant multi-target receptor tyrosine kinase inhibitors for the treatment of gastric cancer

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Xiuli Wu, Zhihao Liu, Cailin Gan, Wei Wei, Qianyu Zhang, Hongyao Liu, Hanyun Que, Xingping Su, Lin Yue, Hualong He, Liang Ouyang, Tinghong Ye

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Structural and biosynthetic studies of botrycinereic acid, a new cryptic metabolite from the fungus Botrytis cinerea

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Ana A. Pinto, Javier E. Barúa, Marilia O. Almeida, Muriel Viaud, David Zorrilla, Isidro G. Collado, Antonio J. Macías-Sánchez, Rosa Durán-Patrón

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Synthesis and biological evaluation of antibacterial activity of novel clarithromycin derivatives incorporating 1,2,3-triazole moieties at the 4”- and 11-OH positions

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Yinhui Qin, Min Sun, Na Zhang, Yan Yang, Peizhi Ma

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

An insight into the interaction between Indisulam and human serum albumin: Spectroscopic method, computer simulation and in vitro cytotoxicity assay

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Bijia Zhou, Hui Zhou, Linlin Xu, Ruirui Cai, Chaolan Chen, Baozhu Chi, Xun Tuo

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Discovery of benzamide derivatives containing urea moiety as soluble epoxide hydrolase inhibitors

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Ye Tian, Shuo Li, Kuan Dong, Xiaolu Su, Siyu Fu, Xuening Lv, Meibo Duan, Ting Yang, Yu Han, Guangda Hu, Jialu Liu, Yanping Sun, Hao Yue, Yongjun Sun, Huimin Zhang, Zhidian…

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

One pot domino synthesis of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thiones (THTTs) as anti-inflammatory and antinociceptive candidates: A proof from in-vivo to in-vitro and in-silico mechanistic studies

Publication date: October 2022Source: Bioorganic Chemistry, Volume 127Author(s): Sumaya Raheem, Rasool Khan, Xiandao Pan, Rahim Ullah, Sobia Ahsan Halim, Ajmal Khan, Ahmed Al-Harrasi

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Bioorganic Chemistry

Scopariusicides D–M, <em>ent</em>-clerodane-based isomeric meroditerpenoids with a cyclobutane-fused <em>γ</em>/<em>δ</em>-lactone core from <em>Isodon scoparius</em>

Bioorganic Chemistry

Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome

Bioorganic Chemistry

Design, synthesis and biological evaluation of <em>N</em>-(4-alkoxy-3-(1<em>H</em>-tetrazol-1-yl)phenyl) heterocyclic aromatic amide derivatives as xanthine oxidase inhibitors

Bioorganic Chemistry

Six pairs of enantiomeric phthalide dimers from the rhizomes of <em>Ligusticum chuanxiong</em> and their absolute configurations and anti-inflammatory activities

Bioorganic Chemistry

Design, synthesis and biological evaluation of a series of novel pyrrolo[2,3-<em>d</em>]pyrimidin/pyrazolo[3,4-<em>d</em>]pyrimidin-4-amine derivatives as FGFRs-dominant multi-target receptor tyrosine kinase inhibitors for the treatment of gastric cancer

Bioorganic Chemistry

Structural and biosynthetic studies of botrycinereic acid, a new cryptic metabolite from the fungus <em>Botrytis cinerea</em>

Bioorganic Chemistry

Synthesis and biological evaluation of antibacterial activity of novel clarithromycin derivatives incorporating 1,2,3-triazole moieties at the <strong>4”</strong>- and 11-OH positions

Bioorganic Chemistry

An insight into the interaction between Indisulam and human serum albumin: Spectroscopic method, computer simulation and <em>in vitro</em> cytotoxicity assay

Bioorganic Chemistry

Discovery of benzamide derivatives containing urea moiety as soluble epoxide hydrolase inhibitors

Bioorganic Chemistry

One pot domino synthesis of new 3,5-disubstituted-tetrahydro-2<em>H</em>-1,3,5-thiadiazine-2-thiones (THTTs) as anti-inflammatory and antinociceptive candidates: A proof from <em>in-vivo</em> to <em>in-vitro</em> and <em>in-silico</em> mechanistic studies