Bioorganic Chemistry

Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone

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By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Novel xanthine oxidase inhibitory peptides derived from whey protein: identification, in vitro inhibition mechanism and in vivo activity validation

Publication date: November 2022Source: Bioorganic Chemistry, Volume 128Author(s): Xiaofen Qi, Haoran Chen, Kaifang Guan, Yue Sun, Rongchun Wang, Qiming Li, Ying Ma

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

A possible covalent xanthine oxidase inhibitor TS10: Inhibition mechanism, metabolites identification and PDPK assessment

Publication date: November 2022Source: Bioorganic Chemistry, Volume 128Author(s): Ting-jian Zhang, Xu Zhang, En-yu Xu, Zhao-ran Wang, Zhen-hao Zhang, Qiu-yin Wang, Lin Wang, Yan-qing Wen, Fan-hao Meng

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Synthesis and aldose reductase inhibition effects of celecoxib derivatives containing pyrazole linked-sulfonamide moiety

Publication date: November 2022Source: Bioorganic Chemistry, Volume 128Author(s): Cetin Bayrak

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Diminishing hERG inhibitory activity of aminopiperidine-naphthyridine linked NBTI antibacterials by structural and physicochemical optimizations

Publication date: November 2022Source: Bioorganic Chemistry, Volume 128Author(s): Maja Kokot, Matjaž Weiss, Irena Zdovc, Marko Anderluh, Martina Hrast, Nikola Minovski

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Novel hit of DPP-4Is as promising antihyperglycemic agents with dual antioxidant/anti-inflammatory effects for type 2 diabetes with/without COVID-19

Publication date: November 2022Source: Bioorganic Chemistry, Volume 128Author(s): Shahenda Mahgoub, Samar S. Fatahala, Amira I. Sayed, Hanaa B. Atya, Mohamed F. El-Shehry, Hala Afifi, Samir M. Awad, Rania H. Abd El-Hameed, Heba Taha

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Facile synthesis, larvicidal activity, biological effects, and molecular docking of sulfonamide-incorporating quaternary ammonium iodides as acetylcholinesterase inhibitors against Culex pipiens L

Publication date: November 2022Source: Bioorganic Chemistry, Volume 128Author(s): Ahmed H. Tantawy, Shaimaa M. Farag, Doaa R. Abdel-Haleem, Hany I. Mohamed

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Synthesis and evaluation of benzoylbenzofurans and isoflavone derivatives as sirtuin 1 inhibitors with antiproliferative effects on cancer cells

Publication date: November 2022Source: Bioorganic Chemistry, Volume 128Author(s): Mamoalosi A. Selepe, Phaladi Kunyane, Pule Seboletswe, Shankari Nair, Nosipho Cele, Monique Engelbrecht, Daniël F. Joubert, Charlot Vandevoorde, Parvesh Singh, Molahlehi …

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Discovery of 1,2,4-triazole derivatives as novel neuroprotectants against cerebral ischemic injury by activating antioxidant response element

Publication date: November 2022Source: Bioorganic Chemistry, Volume 128Author(s): Yaoqiang Lao, Ping Huang, Jianwen Chen, Yang Wang, Ruiqi Su, Weiyan Shao, Wenhao Hu, Jingxia Zhang

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Bioorganic Chemistry

Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2<em>H</em>)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1<em>H</em>,5<em>H</em>)-pyrimidinedione and naloxone/naltrexone

Bioorganic Chemistry

Novel xanthine oxidase inhibitory peptides derived from whey protein: identification, <em>in vitro</em> inhibition mechanism and <em>in vivo</em> activity validation

Bioorganic Chemistry

A possible covalent xanthine oxidase inhibitor TS10: Inhibition mechanism, metabolites identification and PDPK assessment

Bioorganic Chemistry

Synthesis and aldose reductase inhibition effects of celecoxib derivatives containing pyrazole linked-sulfonamide moiety

Bioorganic Chemistry

Diminishing hERG inhibitory activity of aminopiperidine-naphthyridine linked NBTI antibacterials by structural and physicochemical optimizations

Bioorganic Chemistry

Novel hit of DPP-4Is as promising antihyperglycemic agents with dual antioxidant/anti-inflammatory effects for type 2 diabetes with/without COVID-19

Bioorganic Chemistry

Facile synthesis, larvicidal activity, biological effects, and molecular docking of sulfonamide-incorporating quaternary ammonium iodides as acetylcholinesterase inhibitors against <em>Culex pipiens</em> L

Bioorganic Chemistry

Synthesis and evaluation of benzoylbenzofurans and isoflavone derivatives as sirtuin 1 inhibitors with antiproliferative effects on cancer cells

Bioorganic Chemistry

Molecular mechanism of acceptor selection in cyclodextrin glycosyltransferases catalyzed ginsenoside transglycosylation

Bioorganic Chemistry

Discovery of 1,2,4-triazole derivatives as novel neuroprotectants against cerebral ischemic injury by activating antioxidant response element