Bioorganic Chemistry

New anti-inflammatory and non-cytotoxic metabolites of methylstenbolone obtained by microbial transformation

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Muhammad Aamer, Mahwish Siddiqui, Almas Jabeen, Rimsha Irshad, Farooq-Ahmad Khan, Atia-tul-Wahab, M. Iqbal Choudhary, Yan Wang

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Development of fluorescent dual-FRET probe for simultaneous detection of caspase-8 and caspase-9 activities and their relative quantification

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Martin Porubský, Eva Řezníčková, Soňa Křupková, Vladimír Kryštof, Jan Hlaváč

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Structure based design and synthesis of 3-(7-nitro-3-oxo-3,4-dihydroquinoxalin-2-yl)propanehydrazide derivatives as novel bacterial DNA-gyrase inhibitors: In-vitro, In-vivo, In-silico and SAR studies

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Marwa A. Saleh, Ayman Abo Elmaaty, Hoda S. El Saeed, Moustafa M. Saleh, Mohammed Salah, Rogy R. Ezz Eldin

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Natural carbazole alkaloid murrayafoline A displays potent anti-neuroinflammatory effect by directly targeting transcription factor Sp1 in LPS-induced microglial cells

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Chao-Hua Li, Ying Zhou, Peng-Fei Tu, Ke-Wu Zeng, Yong Jiang

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Discovery of a potent EGFR and ALK dual mutation inhibitor containing N-(3-((4-((2-(cyclopropylsulfinyl)phenyl)amino)pyrimidin-2-yl)amino) phenyl)acrylamide scaffold

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Wei Li, Han Yao, Chenxi Gu, Yuanyuan Ren, Jiadai Liu, Baijiao An, Wenhao Hu, Xingshu Li, Albert S.C. Chan

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Prospect of ULK1 modulators in targeting regulatory T cells

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Youngjun Park, Jaebong Jang

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Design, synthesis and pharmacological evaluation of 2-arylurea-1,3,5-triazine derivative (XIN-9): A novel potent dual PI3K/mTOR inhibitor for cancer therapy

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Xin Sun, Binliang Zhang, Leixuan Luo, Yang Yang, Bin He, Qian Zhang, Linxiao Wang, Shan Xu, Pengwu Zheng, Wufu Zhu

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Discovery of novel 1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors with hypouricemic effects

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Yajun Yang, Dingan Yan, Hanzeng Cheng, Guanglei Nan, Xianxin Hou, Long Ren, Ying Yang, Xuechen Li, Jinying Tian, Fei Ye, Zhiyan Xiao

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Novel 1,3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and anticancer agents through selectively targeting COX-2

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Ahmed M.M. Shaker, Mai I. Shahin, Asmaa M. AboulMagd, Seham A. Abdel Aleem, Hamdy M. Abdel-Rahman, Dalal A. Abou El Ella

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

3-Substituted-2,3-Dihydrothiazole as a promising scaffold to design EGFR inhibitors

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Radwan El-Haggar, Sherif F. Hammad, Reem I. Alsantali, Munira M. Alrooqi, Mahmoud A. El Hassab, Nicolas Masurier, Marwa F. Ahmed

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Bioorganic Chemistry

New anti-inflammatory and non-cytotoxic metabolites of methylstenbolone obtained by microbial transformation

Bioorganic Chemistry

Development of fluorescent dual-FRET probe for simultaneous detection of caspase-8 and caspase-9 activities and their relative quantification

Bioorganic Chemistry

Structure based design and synthesis of 3-(7-nitro-3-oxo-3,4-dihydroquinoxalin-2-yl)propanehydrazide derivatives as novel bacterial DNA-gyrase inhibitors: <em>In-vitro</em>, <em>In-vivo</em>, <em>In-silico and SAR studies</em>

Bioorganic Chemistry

Natural carbazole alkaloid murrayafoline A displays potent anti-neuroinflammatory effect by directly targeting transcription factor Sp1 in LPS-induced microglial cells

Bioorganic Chemistry

Discovery of a potent EGFR and ALK dual mutation inhibitor containing <em>N</em>-(3-((4-((2-(cyclopropylsulfinyl)phenyl)amino)pyrimidin-2-yl)amino) phenyl)acrylamide scaffold

Bioorganic Chemistry

Prospect of ULK1 modulators in targeting regulatory T cells

Bioorganic Chemistry

Design, synthesis and pharmacological evaluation of 2-arylurea-1,3,5-triazine derivative (XIN-9): A novel potent dual PI3K/mTOR inhibitor for cancer therapy

Bioorganic Chemistry

Discovery of novel 1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors with hypouricemic effects

Bioorganic Chemistry

Novel 1,3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and anticancer agents through selectively targeting COX-2

Bioorganic Chemistry

3-Substituted-2,3-Dihydrothiazole as a promising scaffold to design EGFR inhibitors