Bioorganic Chemistry

Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential anticancer and anti-inflammatory activities

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Asmaa H.H. Ahmed, Mamdouh F.A. Mohamed, Rasha M. Allam, Ayman Nafady, Shaaban K. Mohamed, Ahmed E. Gouda, Eman A.M. Beshr

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Synthesis and in vivo evaluation of new steviol derivatives that protect against cardiomyopathy by inhibiting ferroptosis

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Chao Xu, E Ou, Zhiyin Li, Zhenyu Chen, Qi Jia, Xiaojia Xu, Liping Luo, Geng Xu, Jiansong Liu, Zhengqiang Yuan, Yu Zhao

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Targeting the kinetics mechanism of AMPA receptor inhibition by 2-oxo-3H-benzoxazole derivatives

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Mohammad Qneibi, Mohammed Hawash, Sosana Bdir, Sultan Nacak Baytas

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Design, synthesis, spectroscopic characterization, in vitro tyrosinase inhibition, antioxidant evaluation, in silico and kinetic studies of substituted indole-carbohydrazides

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Aida Iraji, Negar Sheikhi, Mahshid Attarroshan, Gholam Reaz Sharifi Ardani, Maryam Kabiri, Ali Naghibi Bafghi, Farzad Kobarfard, Zahra Rezaei, Mehdi Khoshneviszadeh, Alir…

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Discovery of selective HDAC6 inhibitors capped by flavonoid or flavonoid-analogous moieties as anti-cancer therapeutics simultaneously harboring anti-proliferative and immunomodulatory activities

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Ge He, Zhi Li, Mingming Zhang, Zeng Li, Yujie Wang, Fang Zhao, Yang Wang, Xiaodong Ma

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Design and synthesis of N-(1-(6-(substituted phenyl)-pyridazin-3-yl)-piperidine-3-yl)-amine derivatives as JMJD6 inhibitors

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Yuqing Qian, Mingtao Ao, Boqun Li, Zhijian Kuang, Xiumei Wang, Yin Cao, Jiayi Li, Yingkun Qiu, Kaiqiang Guo, Meijuan Fang, Zhen Wu

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Allyl phenyl selenides as H2O2 acceptors to develop ROS-responsive theranostic prodrugs

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Xue-Yan Yang, Bo Yuan, Hai Xiong, Yahao Zhao, Lu Wang, San-Qi Zhang, Shuai Mao

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Assessing p-tolyloxy-1,3,4-oxadiazole acetamides as lipoxygenase inhibitors assisted by in vitro and in silico studies

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Bushra Bashir, Naheed Riaz, Syeda Abida Ejaz, Muhammad Saleem, Muhammad Ashraf, Ambar Iqbal, Saima Muzaffar, Samina Ejaz, Aziz-ur-Rehman, Hafiz Mohammad Kashif Mahmood, K…

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Isolation and synthesis of rocaglaol derivatives by inhibiting Wnt/β-catenin and MAPK signaling pathways against colorectal cancer

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Yanan Li, Jie Qiu, Ping Yi, Jue Yang, Wei Gu, Yanmei Li, Chunmao Yuan, Xiaojiang Hao

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Optimization of a cell surface vimentin binding peptoid to extract antagonist effect on lung cancer cells

Publication date: December 2022Source: Bioorganic Chemistry, Volume 129Author(s): Haowen Zhang, D. Gomika Udugamasooriya

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Bioorganic Chemistry

Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential anticancer and anti-inflammatory activities

Bioorganic Chemistry

Synthesis and <em>in vivo</em> evaluation of new steviol derivatives that protect against cardiomyopathy by inhibiting ferroptosis

Bioorganic Chemistry

Targeting the kinetics mechanism of AMPA receptor inhibition by 2-oxo-3<em>H</em>-benzoxazole derivatives

Bioorganic Chemistry

Design, synthesis, spectroscopic characterization, <em>in vitro</em> tyrosinase inhibition, antioxidant evaluation, <em>in silico</em> and kinetic studies of substituted indole-carbohydrazides

Bioorganic Chemistry

Discovery of selective HDAC6 inhibitors capped by flavonoid or flavonoid-analogous moieties as anti-cancer therapeutics simultaneously harboring anti-proliferative and immunomodulatory activities

Bioorganic Chemistry

Design and synthesis of <em>N</em>-(1-(6-(substituted phenyl)-pyridazin-3-yl)-piperidine-3-yl)-amine derivatives as JMJD6 inhibitors

Bioorganic Chemistry

Allyl phenyl selenides as H<sub>2</sub>O<sub>2</sub> acceptors to develop ROS-responsive theranostic prodrugs

Bioorganic Chemistry

Assessing <em>p</em>-tolyloxy-1,3,4-oxadiazole acetamides as lipoxygenase inhibitors assisted by <em>in vitro</em> and <em>in silico</em> studies

Bioorganic Chemistry

Isolation and synthesis of rocaglaol derivatives by inhibiting Wnt/β-catenin and MAPK signaling pathways against colorectal cancer

Bioorganic Chemistry

Optimization of a cell surface vimentin binding peptoid to extract antagonist effect on lung cancer cells