Bioorganic Chemistry

Synthesis of Cy5-Labelled C5-Alkynyl-modified Cytidine Triphosphates via Sonogashira Coupling for DNA Labelling

Publication date: Available online 10 December 2022Source: Bioorganic ChemistryAuthor(s): Viktoriya E. Kuznetsova, Valeriy E. Shershov, Teimur O. Guseinov, Rinat A. Miftakhov, Pavel N. Solyev, Roman A. Novikov, Anna I. Levashova, Alexander S. Zasedatel…

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Chalcone derivatives as xanthine oxidase inhibitors: synthesis, binding mode investigation, biological evaluation, and ADMET prediction

Publication date: Available online 10 December 2022Source: Bioorganic ChemistryAuthor(s): Can Yang, Yi Liu, Yanbei Tu, Lizi Li, Jiana Du, Dehong Yu, Pei He, Tao Wang, Yan Liu, Hao Chen, Yanfang Li

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Design, synthesis, and evaluation of JTE-013 derivatives as novel potent S1PR2 antagonists for recovering the sensitivity of colorectal cancer to 5-fluorouracil

Publication date: Available online 10 December 2022Source: Bioorganic ChemistryAuthor(s): Zhikun Guo, Shuai Zhang, Xiaochun Liu, Guangjian Zhao, Yingzhi Zhang, Dongdong Luo, Xuecui Zhao, Ximing Xu, Xianjun Qu, Lin Li, Shengbiao Wan, Shuxiang Cui

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

New Tetrahydropyrimidine-1,2,3-Triazole Clubbed Compounds: Antitubercular Activity and Thymidine Monophosphate Kinase (TMPKmt) Inhibition

Publication date: Available online 9 December 2022Source: Bioorganic ChemistryAuthor(s): Mai S. El-Shoukrofy, Amal Atta, Salwa Fahmy, Dharmarajan Sriram, Mona A. Mahran, Ibrahim M. Labouta

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Synthesis and cytotoxicity evaluation of DNA-interactive β-carboline indolyl-3-glyoxamide derivatives: Topo-II inhibition and in silico modelling studies

Publication date: Available online 8 December 2022Source: Bioorganic ChemistryAuthor(s): Jay Prakash Soni, G. Nikitha Reddy, Ziaur Rahman, Anamika Sharma, Akella Spandana, Regur Phanindranath, Manoj P. Dandekar, Narayana Nagesh, Nagula Shankaraiah

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Discovery and Structural Optimization of 3-O-β-Chacotriosyl Betulonic Acid Saponins as Potent Fusion Inhibitors of Omicron Virus Infections

Publication date: Available online 8 December 2022Source: Bioorganic ChemistryAuthor(s): Mingjian Liu, Jinshen Wang, Xin Wan, Baixi Li, Mingming Guan, Xiaoyun Ning, Xiaojie Hu, Sumei Li, Shuwen Liu, Gaopeng Song

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

P-Y/G@NHs sensitizes non-small cell lung cancer cells to radiotherapy via blockage of the PI3K/AKT signaling pathway

Publication date: Available online 6 December 2022Source: Bioorganic ChemistryAuthor(s): Lu Zhang, Chong Zhou, Yun Zhou, Wei Zhang, Xiang Hu, Meng Chen, Hui Hui, Ling Guo, Chengjun Wu, Juying Zhou, Haitao Yin

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Schiff Bases as Linker in the Development of Quinoline-Sulfonamide Hybrids as Selective Cancer-Associated Carbonic Anhydrase Isoforms IX/XII Inhibitors: A New Regioisomerism Tactic

Publication date: Available online 5 December 2022Source: Bioorganic ChemistryAuthor(s): Afaf El-Malah, Ehab S. Taher, Andrea Angeli, Samar S. Elbaramawi, Zeinab Mahmoud, Nour Moustafa, Claudiu T. Supuran, Tarek S. Ibrahim

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Design, Synthesis and Molecular modeling study of certain EGFR inhibitors with a Quinazolinone scaffold as Anti-hepatocellular carcinoma and Radio-sensitizers

Publication date: Available online 5 December 2022Source: Bioorganic ChemistryAuthor(s): Walid M. Ghorab, Samiha.A. El-Sebaey, Mostafa M. Ghorab

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Optimisation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as novel Hsp90 C-terminal domain inhibitors against Ewing sarcoma

Publication date: Available online 5 December 2022Source: Bioorganic ChemistryAuthor(s): Živa Zajec, Jaka Dernovšek, Martin Distel, Martina Gobec, Tihomir Tomašič

By ScienceDirect Publication: Bioorganic Chemistry, 2 years ago

Bioorganic Chemistry

Bioorganic Chemistry

Synthesis of Cy5-Labelled C5-Alkynyl-modified Cytidine Triphosphates <em>via</em> Sonogashira Coupling for DNA Labelling

Bioorganic Chemistry

Chalcone derivatives as xanthine oxidase inhibitors: synthesis, binding mode investigation, biological evaluation, and ADMET prediction

Bioorganic Chemistry

Design, synthesis, and evaluation of JTE-013 derivatives as novel potent S1PR2 antagonists for recovering the sensitivity of colorectal cancer to 5-fluorouracil

Bioorganic Chemistry

New Tetrahydropyrimidine-1,2,3-Triazole Clubbed Compounds: Antitubercular Activity and Thymidine Monophosphate Kinase (TMPK<em>mt</em>) Inhibition

Bioorganic Chemistry

Synthesis and cytotoxicity evaluation of DNA-interactive β-carboline indolyl-3-glyoxamide derivatives: Topo-II inhibition and <em>in silico</em> modelling studies

Bioorganic Chemistry

Discovery and Structural Optimization of 3-<em>O</em>-<em>β</em>-Chacotriosyl Betulonic Acid Saponins as Potent Fusion Inhibitors of Omicron Virus Infections

Bioorganic Chemistry

P-Y/G@NHs sensitizes non-small cell lung cancer cells to radiotherapy <em>via</em> blockage of the PI3K/AKT signaling pathway

Bioorganic Chemistry

Schiff Bases as Linker in the Development of Quinoline-Sulfonamide Hybrids as Selective Cancer-Associated Carbonic Anhydrase Isoforms IX/XII Inhibitors: A New Regioisomerism Tactic

Bioorganic Chemistry

Design, Synthesis and Molecular modeling study of certain EGFR inhibitors with a Quinazolinone scaffold as Anti-hepatocellular carcinoma and Radio-sensitizers

Bioorganic Chemistry

Optimisation of pyrazolo[1,5-<em>a</em>]pyrimidin-7(4<em>H</em>)-one derivatives as novel Hsp90 C-terminal domain inhibitors against Ewing sarcoma