Bioorganic Chemistry

Tail-approach based design and synthesis of Arylthiazolylhydrazono-1,2,3-triazoles incorporating sulfanilamide and metanilamide as human carbonic anhydrase I, II, IV and IX inhibitors

Publication date: Available online 26 March 2022Source: Bioorganic ChemistryAuthor(s): Amit Kumar, Kiran Siwach, Tanmay Rom, Rajiv Kumar, Andrea Angeli, Avijit Kumar Paul, Claudiu T. Supuran, Pawan K. Sharma

By ScienceDirect Publication: Bioorganic Chemistry, 3 years ago

Bioorganic Chemistry

Discovery of a Highly Potent CECR2 Bromodomain Inhibitor with 7H-pyrrolo[2,3-d] Pyrimidine Scaffold

Publication date: Available online 26 March 2022Source: Bioorganic ChemistryAuthor(s): Haibo Lu, Tian Lu, Shijia Zu, Zhe Duan, Yiman Guang, Qi Li, Jingyi Ma, Dongying Chen, Bo Li, Wenchao Lu, Hualiang Jiang, Cheng Luo, Deyong Ye, Kaixian Chen, Hua Lin

By ScienceDirect Publication: Bioorganic Chemistry, 3 years ago

Bioorganic Chemistry

Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors

Publication date: May 2022Source: Bioorganic Chemistry, Volume 122Author(s): Fugui Zhu, Xiangguo Meng, Huixin Liang, Chunquan Sheng, Guoqiang Dong, Dan Liu, Shanchao Wu

By ScienceDirect Publication: Bioorganic Chemistry, 3 years ago

Bioorganic Chemistry

Design, synthesis and evaluation of a series of novel long-acting dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes

Publication date: Available online 26 March 2022Source: Bioorganic ChemistryAuthor(s): Chao Lin, Ying Kong, Furong Wang, Rong Rong, Xiangping Li, Rensong Xiao, Ziqi Wu, Qiuyan Zhang, Lin Wang

By ScienceDirect Publication: Bioorganic Chemistry, 3 years ago

Bioorganic Chemistry

Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors

Publication date: May 2022Source: Bioorganic Chemistry, Volume 122Author(s): Manasa Kadagathur, Arbaz Sujat Shaikh, Biswajit Panda, Joel George, Regur Phanindranath, Dilep Kumar Sigalapalli, Nagesh A. Bhale, Chandraiah Godugu, Narayana Nagesh, Nagula S…

By ScienceDirect Publication: Bioorganic Chemistry, 3 years ago

Bioorganic Chemistry

Identification of Small-molecule YAP-TEAD inhibitors by High-throughput docking for the Treatment of colorectal cancer

Publication date: May 2022Source: Bioorganic Chemistry, Volume 122Author(s): Lijun Li, Ruizhe Li, Yumei Wang

By ScienceDirect Publication: Bioorganic Chemistry, 3 years ago

Bioorganic Chemistry

Rheumatoid arthritis drug sinomenine induces apoptosis of cervical tumor cells by targeting thioredoxin reductase in vitro and in vivo

Publication date: May 2022Source: Bioorganic Chemistry, Volume 122Author(s): Dongzhu Duan, Yanru Wang, Dabo Pan, Xiaojie Jin, Yunyun Yan, Peng Song, Le Wang, Jian Xiao, Zihua Wang, Xiaoling Wang

By ScienceDirect Publication: Bioorganic Chemistry, 3 years ago

Bioorganic Chemistry

Cytotoxic triterpene and steroidal glycosides from the seeds of Digitalis purpurea and the synergistic cytotoxicity of steroidal glycosides and etoposide in SBC-3 cells

Publication date: May 2022Source: Bioorganic Chemistry, Volume 122Author(s): Yukiko Matsuo, Hiroko Tsuchihashi, Kazuhiro Takatori, Haruhiko Fukaya, Minpei Kuroda, Yoshihiro Mimaki

By ScienceDirect Publication: Bioorganic Chemistry, 3 years ago

Bioorganic Chemistry

Bioorganic Chemistry

Tail-approach based design and synthesis of Arylthiazolylhydrazono-1,2,3-triazoles incorporating sulfanilamide and metanilamide as human carbonic anhydrase I, II, IV and IX inhibitors

Bioorganic Chemistry

Discovery of a Highly Potent CECR2 Bromodomain Inhibitor with 7<em>H</em>-pyrrolo[2,3-<em>d</em>] Pyrimidine Scaffold

Bioorganic Chemistry

Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors

Bioorganic Chemistry

Design, synthesis and evaluation of a series of novel long-acting dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes

Bioorganic Chemistry

Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors

Bioorganic Chemistry

Identification of Small-molecule YAP-TEAD inhibitors by High-throughput docking for the Treatment of colorectal cancer

Bioorganic Chemistry

Rheumatoid arthritis drug sinomenine induces apoptosis of cervical tumor cells by targeting thioredoxin reductase <em>in vitro and in vivo</em>

Bioorganic Chemistry

Cytotoxic triterpene and steroidal glycosides from the seeds of <em>Digitalis purpurea</em> and the synergistic cytotoxicity of steroidal glycosides and etoposide in SBC-3 cells

Bioorganic Chemistry

Diketopyrrolo[3,4-c]pyrrole derivative as a promising ligand for the stabilization of G-quadruplex DNA structures

Bioorganic Chemistry

Targeting Ship2-Sam with peptide ligands: Novel insights from a multidisciplinary approach