Bioorganic Chemistry

Enhancement efficiency delivery of antiviral Molnupiravir-drug via the loading with self-assembly nanoparticles of pycnogenol and cellulose which are decorated by zinc oxide nanoparticles for COVID-19 therapy

Publication date: Available online 10 December 2023Source: Bioorganic ChemistryAuthor(s): Nagi M. El-Shafai, Yasser S. Mostafa, Mohamed S. Ramadan, Ibrahim El-Mehasseb

By ScienceDirect Publication: Bioorganic Chemistry, 11 months ago

Synthesis, Molecular docking and Biological evaluation of 1,2,4-Oxadiazole based Novel Non-Steroidal Derivatives against Prostate Cancer

Publication date: Available online 10 December 2023Source: Bioorganic ChemistryAuthor(s): Shubham Kumar, Pankaj Wadhwa

By ScienceDirect Publication: Bioorganic Chemistry, 11 months ago

Computational Design, Synthesis, and bioevaluation of 2-(Pyrimidin-4-yl)oxazole-4-carboxamide Derivatives: Dual inhibition of EGFRWT and EGFRT790M with ADMET profiling

Publication date: Available online 10 December 2023Source: Bioorganic ChemistryAuthor(s): Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph

By ScienceDirect Publication: Bioorganic Chemistry, 11 months ago

A near-infrared aggregation-induced emission photosensitizer targeting mitochondria for depleting Cu2+ to trigger light-activated cancer cells oncosis

Publication date: Available online 10 December 2023Source: Bioorganic ChemistryAuthor(s): Ke Xue, Yongfei Zhao, Saidong Sun, Yuanhang Li, Zhengjian Qi

By ScienceDirect Publication: Bioorganic Chemistry, 11 months ago

NQO-1 activatable NIR photosensitizer for visualization and selective killing of breast cancer cells

Publication date: Available online 9 December 2023Source: Bioorganic ChemistryAuthor(s): Zhipeng Li, Qincong Feng, Jiting Hou, Jianliang Shen

By ScienceDirect Publication: Bioorganic Chemistry, 11 months ago

Divergent synthesis of fractionated Cannabis sativa extract led to multiple cannabinoids C-&O-glycosides with anti-proliferative/anti-metastatic properties

Publication date: Available online 9 December 2023Source: Bioorganic ChemistryAuthor(s): Yedukondalu Nalli, Khalid Bashir Mir, Tanzeeba Amin, Veeranjaneyulu Gennedi, Ehtesham Jameel, Anindya Goswami, Asif Ali

By ScienceDirect Publication: Bioorganic Chemistry, 11 months ago

Corrigendum to “Novel spirooxindole based benzimidazole scaffold: In vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinofvma” [Bioorg. Chem. 129 (2022) 106124]

Publication date: Available online 8 December 2023Source: Bioorganic ChemistryAuthor(s): Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, Matti Haukka, Marwa M. Abu-Serie, Alexander Dömling, Eman A. Mazyed, Farid A. …

By ScienceDirect Publication: Bioorganic Chemistry, 11 months ago

Bioorganic Chemistry

Design, synthesis, and biological evaluation of N-(pyridin-3-yl)pyrimidin-4-amine analogues as novel cyclin-dependent kinase 2 inhibitors for cancer therapy

Publication date: Available online 8 December 2023Source: Bioorganic ChemistryAuthor(s): Wen-Bin Zeng, Tang-Yang Ji, Yan-Ting Zhang, Yu-Feng Ma, Rou Li, Wen-Wei You, Pei-Liang Zhao

By ScienceDirect Publication: Bioorganic Chemistry, 11 months ago

Bioorganic Chemistry

Green approach to the synthesis of α-aminophosphonate-tetrahydroisoquinoline hybrids and their anti-cholinesterase activity

Publication date: Available online 8 December 2023Source: Bioorganic ChemistryAuthor(s): Joaquín Marchán-García, Eduardo Buxaderas, Dante Nicolas Stratico, Victoria Richmond, Valeria Cavallaro, Ana P. Murray, Gabriel Radivoy, Yanina Moglie

By ScienceDirect Publication: Bioorganic Chemistry, 11 months ago

Bioorganic Chemistry

Discovery of α-Ketoamide inhibitors of SARS-CoV-2 main protease derived from quaternized P1 groups

Publication date: Available online 6 December 2023Source: Bioorganic ChemistryAuthor(s): Qiao Huang, Baoxue Quan, Yan Chen, Xiu Zhao, Yanmei Zhou, Chong Huang, Jingxin Qiao, Yifei Wang, Yueyue Li, Shengyong Yang, Jian Lei, Linli Li

By ScienceDirect Publication: Bioorganic Chemistry, 11 months ago

Bioorganic Chemistry

Bioorganic Chemistry

Enhancement efficiency delivery of antiviral Molnupiravir-drug via the loading with self-assembly nanoparticles of pycnogenol and cellulose which are decorated by zinc oxide nanoparticles for COVID-19 therapy

Bioorganic Chemistry

Synthesis, Molecular docking and Biological evaluation of 1,2,4-Oxadiazole based Novel Non-Steroidal Derivatives against Prostate Cancer

Bioorganic Chemistry

Computational Design, Synthesis, and bioevaluation of 2-(Pyrimidin-4-yl)oxazole-4-carboxamide Derivatives: Dual inhibition of EGFR<sup>WT</sup> and EGFR<sup>T790M</sup> with ADMET profiling

Bioorganic Chemistry

A near-infrared aggregation-induced emission photosensitizer targeting mitochondria for depleting Cu<sup>2+</sup> to trigger light-activated cancer cells oncosis

Bioorganic Chemistry

NQO-1 activatable NIR photosensitizer for visualization and selective killing of breast cancer cells

Bioorganic Chemistry

Divergent synthesis of fractionated <em>Cannabis sativa</em> extract led to multiple cannabinoids C-&O-glycosides with anti-proliferative/anti-metastatic properties

Bioorganic Chemistry

Corrigendum to “Novel spirooxindole based benzimidazole scaffold: <em>In vitro</em>, nanoformulation and <em>in vivo</em> studies on anticancer and antimetastatic activity of breast adenocarcinofvma” [Bioorg. Chem. 129 (2022) 106124]

Bioorganic Chemistry

Design, synthesis, and biological evaluation of <em>N</em>-(pyridin-3-yl)pyrimidin-4-amine analogues as novel cyclin-dependent kinase 2 inhibitors for cancer therapy

Bioorganic Chemistry

Green approach to the synthesis of α-aminophosphonate-tetrahydroisoquinoline hybrids and their anti-cholinesterase activity

Bioorganic Chemistry

Discovery of α-Ketoamide inhibitors of SARS-CoV-2 main protease derived from quaternized <em>P</em>1 groups