Expanding limits of artificial enzymes: unprecedented catalysis by an oxidase nanozyme in activating a structural protein for covalent crosslinking and conferring remarkable proteolytic resistance

Chem. Sci., 2024, 15,14726-14738
DOI: 10.1039/D4SC03767G, Edge Article

Open Access

&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Adarsh P. Fatrekar, Rasmi V. Morajkar, Amit A. Vernekar
New properties of nanozymes are vital for their advancement. We reveal an oxidase nanozyme’s unique role in activating tyrosyl residues for collagen crosslinking with tannic acid, imparting 100% collagenase resistance to crosslinked collagen tendons.
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