Department of Animal Biology

Nature Immunology

Nature Immunology

Whole-genome profiling of DNA methylation and hydroxymethylation identifies distinct regulatory programs among innate lymphocytes

Nature Immunology, Published online: 24 March 2022; doi:10.1038/s41590-022-01164-8Colonna and colleagues present a genome-wide characterization of DNA methylation and hydroxymethylation in innate lymphocytes and identify differentially…

By Vincent Peng, 4 years ago
Nature Immunology

IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

Nature Immunology, Published online: 24 March 2022; doi:10.1038/s41590-022-01160-yRNA vaccines have been associated with high reactogenicity. Mellman and colleagues demonstrate that lipid-formulated RNA vaccines trigger IL-1 production…

By Siri Tahtinen, 4 years ago
Nature Immunology

Author Correction: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

Nature Immunology, Published online: 24 March 2022; doi:10.1038/s41590-022-01180-8Author Correction: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

By Haifa H. Jabara, 4 years ago
Nature Immunology

Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity

Nature Immunology, Published online: 21 March 2022; doi:10.1038/s41590-022-01153-xTumor-associated macrophages can restrict antitumor responses. Barreira da Silva and colleagues demonstrate that the intracellular enzyme QPCTL supports …

By Rosa Barreira da Silva, 4 years ago
Nature Immunology

Modulating the tumor-associated macrophage landscape

Nature Immunology, Published online: 21 March 2022; doi:10.1038/s41590-022-01159-5Targeting the post-translational modification enzyme QPCTL prevents the protection of CCL2 and CCL7 from N-terminal degradation, inactivates their chemot…

By Alexandre Boissonnas, 4 years ago

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