Nature Immunology, Published online: 23 August 2024; doi:10.1038/s41590-024-01933-7By use of a degron-mediated acute protein degradation model, Schwickert and colleagues are able to distinguish between direct and indirect gene targets …
Nature Immunology, Published online: 23 August 2024; doi:10.1038/s41590-024-01931-9Appay and colleagues show that long-term antiretroviral therapy is associated with clonal succession of HIV-1-specific CD8+ T cell populations, which ev…
Nature Immunology, Published online: 23 August 2024; doi:10.1038/s41590-024-01943-5Here the authors provide a resource for ovarian cancer combining spatial transcriptomics, genomics, CRISPR Perturb-seq screens and in silico methods to …
Nature Immunology, Published online: 23 August 2024; doi:10.1038/s41590-024-01924-8HIV-specific CD8+ T cells are dysfunctional in the majority of people living with HIV. However, long-term treatment with antiretroviral therapy may cons…
Nature Immunology, Published online: 21 August 2024; doi:10.1038/s41590-024-01932-8Tumor immunoediting occurs early during tumorigenesis and is thereby difficult to study. Here the authors overcome this issue using an aggressive breast…
Nature Immunology, Published online: 21 August 2024; doi:10.1038/s41590-024-01922-wSun Hur and colleagues examine the mechanism of Aire protein function underlying peripheral tissue antigen gene expression in thymic mTECs. They show th…
Nature Immunology, Published online: 21 August 2024; doi:10.1038/s41590-024-01940-8The AIRE protein drives the expression of tissue-restricted self-antigens, required to induce immune tolerance for self-proteins. New work shows the imp…
Nature Immunology, Published online: 21 August 2024; doi:10.1038/s41590-024-01941-7Profiling of T cell responses in the lungs of patients with pneumonia revealed that early and persistent enrichment of T cells correlates with survival …
Nature Immunology, Published online: 20 August 2024; doi:10.1038/s41590-024-01926-6Schattgen et al. profiled the subsets and clonality of CD4+ TFH cells in the blood and lymph nodes of human volunteers who received two influenza vaccin…
Nature Immunology, Published online: 20 August 2024; doi:10.1038/s41590-024-01888-9Mudd, Ellebedy and colleagues integrate single-cell transcriptomics and TCR sequencing to characterize the spike-specific CD4+ TFH cell response in the …