Nature Immunology
Inflammatory macrophages
Nature Immunology, Published online: 28 June 2022; doi:10.1038/s41590-022-01261-8Inflammatory macrophages
Nature Immunology
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition
Nature Immunology, Published online: 27 June 2022; doi:10.1038/s41590-022-01238-7LAG3 inhibits T cell activation, but exactly how it does so has been unclear given a lack of structural information. Here the authors provide the crystal …
Nature Immunology
Extrathymic expression of Aire controls the induction of effective T<sub>H</sub>17 cell-mediated immune response to <i>Candida albicans</i>
Nature Immunology, Published online: 27 June 2022; doi:10.1038/s41590-022-01247-6Abramson and colleagues show that Aire+MHCII+ ILC3s sense, internalize and present Candida albicans and modulate the induction of C. albicans-specific TH1…
Nature Immunology
Overcoming the LAG3 phase problem
Nature Immunology, Published online: 27 June 2022; doi:10.1038/s41590-022-01239-6Lymphocyte activation gene 3 (LAG3) is an important checkpoint inhibitor molecule of immunotherapeutic interest. New crystal structures of LAG3 provide im…
Nature Immunology
Extrathymic Aire primes <i>Candida</i>-specific T<sub>H</sub>17 cells
Nature Immunology, Published online: 27 June 2022; doi:10.1038/s41590-022-01252-9Extrathymic MHCII+Rorc+ Aire-expressing cells that share characteristics with type 3 innate lymphoid cells (ILC3s) internalize C. albicans and present its…
Nature Immunology
B cells regulate hematopoietic stem cells via cholinergic signaling
Nature Immunology, Published online: 28 March 2022; doi:10.1038/s41590-022-01172-8B-cell-derived acetylcholine initiates a circuit that prompts bone marrow stromal cells to secrete factors that restrain the blood-forming activity of he…
Nature Immunology
Retention of immune cells in cribriform lymphatics is induced by neuroinflammation
Nature Immunology, Published online: 28 March 2022; doi:10.1038/s41590-022-01162-wCribriform plate-resident lymphatic endothelial cells respond to neuroinflammatory signals by inducing functional changes that enhance the capture and pr…
Nature Immunology
Neuroinflammation creates an immune regulatory niche at the meningeal lymphatic vasculature near the cribriform plate
Nature Immunology, Published online: 28 March 2022; doi:10.1038/s41590-022-01158-6Fabry and colleagues show that cribriform plate-resident lymphatic endothelial cells respond to neuroinflammatory signals by inducing functional changes …
Nature Immunology
Whole-genome profiling of DNA methylation and hydroxymethylation identifies distinct regulatory programs among innate lymphocytes
Nature Immunology, Published online: 24 March 2022; doi:10.1038/s41590-022-01164-8Colonna and colleagues present a genome-wide characterization of DNA methylation and hydroxymethylation in innate lymphocytes and identify differentially…
Nature Immunology
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines
Nature Immunology, Published online: 24 March 2022; doi:10.1038/s41590-022-01160-yRNA vaccines have been associated with high reactogenicity. Mellman and colleagues demonstrate that lipid-formulated RNA vaccines trigger IL-1 production…