Nature Immunology, Published online: 26 October 2022; doi:10.1038/s41590-022-01327-7Here, the authors use single-cell multiomics and profiling of mitochondrial mutations as endogenous barcodes to show that human adaptive NK cells induc…
Nature Immunology, Published online: 26 October 2022; doi:10.1038/s41590-022-01336-6Clonal expansion and immunological memory of lymphocytes provide protective immunity against repeated pathogen exposure in mammals. New technologies ar…
Nature Immunology, Published online: 21 October 2022; doi:10.1038/s41590-022-01335-7CD40 has long been known as a co-stimulatory molecule involved in T cell help for dendritic cells, and thereby as a contributor to CD8+ T cell immunity…
Nature Immunology, Published online: 21 October 2022; doi:10.1038/s41590-022-01347-3Effective vaccines elicit neutralizing antibodies and long-lasting memory, but this can be challenging with some pathogens, such as HIV. A new study sh…
Nature Immunology, Published online: 21 October 2022; doi:10.1038/s41590-022-01339-3Lai and colleagues show that the RNA helicase DDX5 mediates the alternative splicing of the IL-36R mRNA in keratinocytes and modulates skin inflammatio…
Nature Immunology, Published online: 21 October 2022; doi:10.1038/s41590-022-01324-wCD40 is typically understood as a costimulatory molecule. Here, the authors show CD4+ T cell-induced CD40 signaling in conventional type 1 dendritic ce…
Nature Immunology, Published online: 21 October 2022; doi:10.1038/s41590-022-01338-4Wherry and colleagues provide a comparative analysis of paired single-cell RNA-sequencing and single-cell assay for transposase-accessible chromatin se…
Nature Immunology, Published online: 21 October 2022; doi:10.1038/s41590-022-01325-9Draber and colleagues show that the tetra-transmembrane protein CMTM4 is a subunit of the IL-17 receptor.
Nature Immunology, Published online: 20 October 2022; doi:10.1038/s41590-022-01326-8Wen and colleagues show that the transmembrane protein SUSD2 is a specific negative regulator of CD8+ T cells activation in the tumor environment by in…
Nature Immunology, Published online: 03 October 2022; doi:10.1038/s41590-022-01319-7Akin to adult stem cells, precursor exhausted T cells are hierarchically organized, with long-lived CD62L+ stem-like T cells at the apex of the system….